Hemoglobin desaturation: its occurrence during sleep in patients with cystic fibrosis.
Hemoglobin desaturation: its occurrence during sleep in patients with cystic fibrosis.
复制标题
血红蛋白去饱和：囊性纤维化患者睡眠期间发生的情况。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
A. C. Bryan
中科院分区：
文献类型：
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作者：
P. Francis;N. Muller;D. Gurwitz;D. Milligan;H. Levison;A. C. Bryan
对20例临床稳定的囊性纤维化(CF)患者(平均年龄18.2岁)进行了睡眠研究，以确定睡眠期间血红蛋白饱和度(SaO2)下降的幅度，并将这些变化与肺功能和超声心动图结果联系起来。5名健康青年作为对照。在两组中，SaO2下降最大的是在快速眼动(REM)睡眠期间。对照组在REM睡眠期间的平均最大下降率为2.0%(范围为1%至3%)，而CF组为7.4%(范围为1%至23%)。在11例获得右室收缩时间间期的患者中，9例在REM睡眠期间SaO2下降>3%的患者中有8例超声心动图显示有肺动脉高压。睡眠中反复出现的低饱和度可能有助于慢性阻塞性肺疾病患者肺心病的发生发展。
Sleep studies were performed in 20 clinically stable cystic fibrosis (CF) patients (mean age, 18.2 years) to determine the magnitude of fall in hemoglobin saturation (Sao2) during sleep and to relate these changes to pulmonary function and echocardiographic findings. Five healthy young adults served as controls. In both groups, the maximum fall in Sao2 was seen during rapid eye movement (REM) sleep. The mean maximum fall in the control group during REM sleep was 2.0% (range, 1% to 3%), compared with 7.4% (range, 1% to 23%) in the CF group. Of the 11 patients in whom right ventricular systolic time intervals were obtained, eight of the nine patients with falls in Sao2 greater than 3% during REM sleep had echocardiographic evidence of pulmonary hypertension. Repeated episodes of desaturation during sleep may contribute to the development and progression of cor pulmonale in CF patients.