In vitro efficacy of a copper iodine complex PPE disinfectant for SARS-CoV-2 inactivation.
In vitro efficacy of a copper iodine complex PPE disinfectant for SARS-CoV-2 inactivation.
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DOI：
10.12688/f1000research.24651.2
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Paessler S
中科院分区：
文献类型：
--
作者：
Mantlo E;Rhodes T;Boutros J;Patterson-Fortin L;Evans A;Paessler S
背景：保护工人和医护人员免受导致2019年冠状病毒病的病毒--新冠肺炎(SARS-CoV-2)感染的能力令人高度关注。医院、疗养院和雇主正在根据CDC、OSHA、FDA和其他政府机构等领先公共卫生组织的指导采取感染控制策略。某些硬面消毒剂对SARS-CoV-2有效，但不适合用于皮肤或接触皮肤的个人防护装备(PPE)。此外，几乎无处不在的酒精洗手液可以用于皮肤，但不适合用于个人防护用品。个人防护用品，特别是口罩，也经常被使用的时间比正常更长。需要新的产品和技术，能够在佩戴期间有效地消毒个人防护用品，而不会对周围皮肤产生有害影响。ClyraGuard喷雾是一种新型铜碘络合物，专用于非关键个人防护设备。方法：在本研究中，检测了ClyraGuard铜碘络合物在溶液中对SARS-CoV-2的灭活能力。结果：这些数据表明，该产品有效地以时间依赖的方式降低SARS-CoV-2滴度，病毒在30分钟内降至检测限值以下。结论：这些结果表明，ClyraGuard可能是一种有效的工具，可以减轻可能接触SARS-CoV-2的非危重个人防护用品的交叉污染。
Background: The ability to protect workers and healthcare professionals from infection by SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is of great concern. Hospitals, nursing homes and employers are adopting infection control strategies based on guidance from leading public health organizations such as the CDC, OSHA, FDA, and other government bodies. Certain hard surface disinfectants are effective against SARS-CoV-2 but are not suitable for use on skin or personal protective equipment (PPE) that comes into contact with skin. Furthermore, near-ubiquitous alcohol-based hand sanitizers are acceptable for use on skin, but they are not suitable for use on PPE. PPE, especially masks, are also commonly being used for longer durations than normal. There is a need for new products and techniques that can effectively disinfect PPE during wear time without having detrimental effects on surrounding skin. Clyraguard spray is a novel copper iodine complex designed to be used on non-critical PPE. Methods: In this study, the Clyraguard copper iodine complex was tested for its ability to inactivate SARS-CoV-2 in solution. Results: These data indicate the product to be effective in reducing SARS-CoV-2 titers in a time-dependent manner, with the virus being reduced below the detection limits within 30 minutes. Conclusions: These results suggest that Clyraguard may be an effective tool for mitigating cross-contamination of non-critical PPE that may come into contact with SARS-CoV-2.