The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome
The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome
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DOI：
10.1073/pnas.95.14.8124
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发表时间：
1998-07-07
影响因子：
11.1
通讯作者：
Lal, AA
中科院分区：
文献类型：
--
作者：
Escalante, AA;Freeland, DE;Lal, AA
本文报道了基于线粒体基因组细胞色素b蛋白编码基因的灵长类疟疾寄生虫的系统发育分析。我们研究了17种疟原虫，其中包括14种寄生在灵长类的疟原虫。在我们的分析中，我们使用了四个种来建立疟原虫系统树：两个来自密切相关的属(肝孢子虫和柱状血蛋白)和另外两个复合体(弓形虫和小泰勒虫)，我们发现灵长类疟疾寄生虫形成了一个单系群，唯一的例外是恶性疟原虫、雷氏疟原虫谱系。包括两种非疟原虫血孢子虫的系统发育分析表明，疟原虫属是多系统发育的，我们得出结论，周期性和复发能力等生物学特征在评价疟原虫物种间的系统发育关系方面价值有限。例如，我们没有发现将毒力与宿主-寄生虫关联的年龄联系起来的证据。我们的研究还显示，灵长类疟疾寄生虫起源于非洲，这与目前认为东南亚是其起源中心的观点相矛盾。我们认为，亚洲猴寄生虫的辐射是最近发生的事件，其中几个生活史特征，如周期性差异，从头开始出现。
We report a phylogenetic analysis of primate malaria parasites based on the gene encoding the cytochrome b protein from the mitochondrial genome, We have studied 17 species of Plasmodium, including 14 parasitic in primates. In our analysis, four species were used for rooting the Plasmodium phylogenetic tree: two from closely related genera (Hepatocystis sp, and Haemoproteus columbae) and two other Apicomplexa (Toxoplasma gondii and Theileria parva), We found that primate malaria parasites form a monophyletic group, with the only exception being the Plasmodium falciparum Plasmodium reichenowi lineage. Phylogenetic analyses that include two species of non-Plasmodium Haemosporina suggest that the genus Plasmodium is polyphyletic, We conclude that the biologic traits, such as periodicity and the capacity to relapse, have limited value for assessing the phylogenetic relationships among Plasmodium species. For instance, we found no evidence that would link virulence with the age of the host-parasite association. Our studies also reveal that the primate malaria parasites originated in Africa, which contradicts the presently held opinion of Southeast Asia as their center of origin. We propose that the radiation of Asian monkey parasites is a recent event where several life history traits, like differences in periodicity, appeared de novo.