Immunohistochemical and clinicopathological study regarding nardilysin on extramammary Paget's disease
Immunohistochemical and clinicopathological study regarding nardilysin on extramammary Paget's disease
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甘松素治疗乳房外佩吉特病的免疫组织化学和临床病理学研究
DOI：
10.1007/s00403-023-02579-5
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发表时间：
2023
影响因子：
3
通讯作者：
Fujimoto Noriki
中科院分区：
文献类型：
--
作者：
Yamaguchi Akihiko;Takahashi Toshifumi;Kato Takeshi;Tanaka Toshihiro;Nishi Eiichiro;Fujimoto Noriki
据报道，水松素（NRDC）是一种调节多种生长因子和细胞因子的金属肽链内切酶，它与恶性肿瘤存在着相互矛盾的关系，它促进胃癌、肝细胞癌和结直肠癌的发生，并抑制胰腺导管腺癌的发生。然而，目前尚未研究 NRDC 与皮肤恶性肿瘤的关系。免疫组织化学染色显示，在所有乳房外佩吉特病 (EMPD) 病例中均观察到 NRDC 表达。值得注意的是，其他皮肤恶性肿瘤，包括基底细胞癌、鳞状细胞癌和小汗腺汗孔癌，在免疫组织化学中并未显示 NRDC 表达增加。 EMPD 通常呈现包括结节在内的多种类型的病变，并且无论病变类型如何，均观察到 EMPD 上 NRDC 的阳性染色。使用从结节性病变中采集的样本进行的检查表明，某些病例在每个病变内表现出异质的 NRDC 表达。我们还发现，在一些病例中，EMPD 皮损边缘部分的 NRDC 染色弱于中央部分，并且在这些病例中，肿瘤细胞往往分布在肉眼可见的皮损之外。据推测，皮损边缘区 NRDC 表达减少可能与肿瘤细胞产生 EMPD 皮肤表现的能力有关。这项研究表明，像之前报道的其他恶性肿瘤一样，NRDC 可能与 EMPD 相关。
It has been reported that nardilysin (NRDC), a metalloendopeptidase which regulates various growth factors and cytokines, is associated with malignancies in a conflicting manner, in which it promoted gastric, hepatocellular, and colorectal cancers and suppressed pancreatic ductal adenocarcinoma. However, it has not been investigated how NRDC is associated with cutaneous malignancies for now. Immunohistochemical staining has revealed that NRDC expression is observed in all extramammary Paget's disease (EMPD) cases. Notably, other cutaneous malignancies including basal cell carcinoma, squamous cell carcinoma, and eccrine porocarcinoma, did not show increased NRDC expression in immunohistochemistry. EMPD typically presents several types of lesions including nodules, and positive staining of NRDC on EMPD was observed regardless of the type of lesions. Examination using samples taken from nodular lesions showed that some cases showed heterogenous NRDC expression within each lesion. We also found that NRDC staining was weaker in the marginal parts of EMPD lesion than in the central parts in several cases, and tumor cells tend to be distributed beyond the macroscopic skin lesions in these cases. It was speculated that decreased NRDC expression in the marginal zones of the skin lesions may be associated with the ability of tumor cells to produce the cutaneous manifestation of EMPD. This study suggests that NRDC may be associated with EMPD like other malignancies reported previously.
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利弗皮肤组织病理学
影响因子：
--
作者：
A. Ackerman
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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