Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging
Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging
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用于顺铂 (IV) 输送和生物医学成像的多功能上转换纳米晶体/聚合物纳米复合材料的合理设计
DOI：
10.1002/adma.201301713
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发表时间：
2013-09-20
影响因子：
29.4
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Ma, Ping'an;Xiao, Haihua;Lin, Jun
通过将上转换纳米颗粒与顺铂（IV）前药相结合，我们已经证明可以设计一种稳定的多功能药物递送系统，该系统既可以减少顺铂的缺点，又可以深入了解其体外/体内成像。上/下转换荧光是可检测的并且显示出明显的共定位，表明纳米颗粒在细胞内相当稳定并且保留了UCNP和嵌段共聚物。
By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.