Organ Accumulation in Mice After Inhalation of Single or Mixed Essential Oil Compounds
Organ Accumulation in Mice After Inhalation of Single or Mixed Essential Oil Compounds
复制标题
吸入单一或混合精油化合物后小鼠的器官积聚
DOI：
10.1002/ptr.4723
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发表时间：
2013
影响因子：
7.2
通讯作者：
K. Koike
中科院分区：
文献类型：
--
作者：
T. Satou;Mizuho Takahashi;Hikaru Kasuya;Shio Murakami;S. Hayashi;K. Sadamoto;K. Koike
精油由多种成分组成。据认为，精油的效果是由于特定的成分比例，这可能不同于精油被吸收时的原始比例。然而，这方面的详细研究很少。研究了小鼠吸入单一组分和混合组分后挥发油组分的分布。本研究以新疆山姜（Alpinia zerumbet（Xinjiang.）B。L.伯特和R. M.公司简介α-蒎烯、对伞花烃、1，8-桉叶油素和柠檬烯。在吸入单一或混合组分90分钟后，测量小鼠脑和肝脏中的组分水平。结果表明，混合组分吸入后大脑和肝脏中α-蒎烯的量是单组分吸入后的两倍。在混合吸入组分的比较中，α-蒎烯的比例增加到约1，8-桉叶油素的三倍。据认为，通过鼻粘液的吸收极大地影响了这种现象。精油挥发性成分在人体内分布的研究结果可能为阐明其作用提供线索。版权所有© 2012约翰威利父子有限公司.
Essential oils are composed of multiple components. It is thought that the effect of essential oils is due to specific component ratios, which may differ from the original ratio when the essential oil is absorbed. However, very little detailed research exists in this area. We studied the distribution of essential oil components after inhalation of single and mixed components in mice. This research was done using four main components of Alpinia zerumbet (Pers.) B. L. Burtt. and R. M. Sm.: α‐pinene, p‐cymene, 1,8‐cineole, and limonene. After inhalation of single or mixed components for 90 min, component levels in the brain and liver of mice were measured. The results indicated that the amount of α‐pinene in the brain and liver was twofold greater after mixed‐component inhalation than that after single‐component inhalation. In a comparison of the components of the mixed inhalation, the ratio of α‐pinene increased to about three times that of 1,8‐cineole. It is thought that the absorption via the nasal mucus greatly influences this phenomenon. The results of this investigation of the bodily distribution of essential oil volatile components may provide clues for elucidating their action. Copyright © 2012 John Wiley & Sons, Ltd.