Immunohistologic Findings in Otosclerosis
Immunohistologic Findings in Otosclerosis
复制标题
耳硬化症的免疫组织学发现
DOI：
--
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Benno Weber
中科院分区：
文献类型：
--
作者：
M. Schrader;Joerg Poppendieck;Benno Weber
耳硬化症的病因尚不清楚。在1981年至1988年期间，我们获得了186例在镫骨切除术过程中的耳颅骨活检标本。对标本的连续切片进行组织学（H & E）和免疫组织学（过氧化物酶-抗过氧化物酶技术）检查，以检测免疫球蛋白G、免疫球蛋白M、C1 q和C3补体。活动性耳硬化灶61例，其中43例有IgG沉积。IgM抗体不存在。在非活动性耳硬化症标本中，IgG和IgM不明显。C1 q和C3补体被证明与IgG一起，但有时也在粘膜独立的阶段的耳硬化症。我们的研究结果表明，免疫过程可能是重要的耳硬化症的发病机制。
The cause of otosclerosis is still unclear. Between 1981 and 1988 we obtained 186 biopsy specimens of otosclerotic bone during the course of stapedectomies. Serial sections of the specimens were examined histologically (H & E) and immunohistologically (peroxidase-antiperoxidase technique) for immunoglobulin G, immunoglobulin M, and C1q and C3 complements. Active otosclerotic foci were found in 61 cases, 43 of which had IgG deposits. IgM antibodies were absent. In specimens with inactive otosclerosis, IgG and IgM were not evident. C1q and C3 complements were demonstrated together with IgG, but sometimes also in the mucosa independent of the phase of the otosclerosis. Our findings suggest that an immunologic process may be important in the pathogenesis of otosclerosis.