Lesions of the cerebellar vermis and cerebellar hemispheres: effects on heart rate conditioning in rats.
Lesions of the cerebellar vermis and cerebellar hemispheres: effects on heart rate conditioning in rats.
复制标题
小脑蚓部和小脑半球的损伤：对大鼠心率调节的影响。
作者：
W. F. Supple;R. N. Leaton
本文观察了小脑损伤对大鼠心率条件反应获得的影响。小脑蚓部的大的病变严重衰减收购限制大鼠的差异条件心动过缓反应，而不影响非条件的HR反应的音调条件刺激（CS）或休克非条件刺激（UCS）。在第二个实验中，大鼠不受限制地训练，在这些条件下，对照动物的CR是心动过速。小脑蚓部的病变再次严重减弱了CR的获得，而不影响对CS或UCS的无条件反应。双侧小脑半球病变不影响HR条件反射在任何测试程序。可以得出结论，小脑蚓部是一个必要的组成部分，在大鼠的HR条件电路。小脑半球，这是至关重要的参与一些离散的躯体运动CR，显然没有必要的功能的贡献，人力资源条件反射。这些实验的结果涉及中线小脑蚓部在自主调节的关系，从前脑系统参与HR调节和小脑侧部的贡献离散somatomotor CR的贡献进行了讨论。
The effects of lesions of the cerebellum on the acquisition of heart rate (HR) conditioned responses (CRs) were examined in rats. Large lesions of the cerebellar vermis severely attenuated the acquisition of differentially conditioned bradycardic responses in restrained rats without affecting unconditioned HR responses to the tone conditioned stimuli (CSs) or the shock unconditioned stimulus (UCS). In a second experiment, rats were trained unrestrained, and under these conditions the CR was tachycardia in control animals. Lesions of the vermis again severely attenuated acquisition of this CR without affecting unconditioned responses to the CSs or UCS. Bilateral lesions of the cerebellar hemispheres did not affect HR conditioning in either test procedure. It is concluded that the vermis of the cerebellum is an essential component of an HR conditioning circuit in the rat. The cerebellar hemispheres, which are critically involved in some discrete somatomotor CRs, apparently have no essential functional contribution to HR conditioning. The results of these experiments implicating the midline cerebellar vermis in autonomic conditioning are discussed in relation to contributions from a forebrain system involved in HR conditioning and in relation to lateral cerebellar contributions to discrete somatomotor CRs.