Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
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DOI：
10.1016/j.neuron.2008.04.009
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发表时间：
2008-05-22
期刊：
影响因子：
16.2
通讯作者：
Fehr, Ernst
中科院分区：
文献类型：
--
作者：
Baumgartner, Thomas;Heinrichs, Markus;Fehr, Ernst
信任与背叛信任在人类社会中普遍存在。最近的行为证据表明，神经肽催产素增加了人类之间的信任，从而提供了一个独特的机会，以获得更深入的了解神经机制的信任和适应违反信任。我们通过鼻内、双盲、催产素给药和功能磁共振成像相结合的方法研究了信任行为的神经回路。我们发现，催产素组的受试者在得知自己的信任多次被破坏后，他们的信任行为没有发生变化，而接受安慰剂的受试者的信任度却降低了。信任适应的这种差异与接受催产素的受试者杏仁核、中脑区域和背侧纹状体的激活的特定减少有关，这表明神经系统介导恐惧处理（杏仁核和中脑区域）和反馈信息的行为适应（背侧纹状体）调节催产素对信任的影响。这些发现可能有助于更深入地了解社交恐惧症和自闭症等精神障碍，其特征是持续恐惧或避免社交互动。
Trust and betrayal of trust are ubiquitous in human societies. Recent behavioral evidence shows that the neuropeptide oxytocin increases trust among humans, thus offering a unique chance of gaining a deeper understanding of the neural mechanisms underlying trust and the adaptation to breach of trust. We examined the neural circuitry of trusting behavior by combining the intranasal, double-blind, administration of oxytocin with fMRI. We find that subjects in the oxytocin group show no change in their trusting behavior after they learned that their trust had been breached several times while subjects receiving placebo decrease their trust. This difference in trust adaptation is associated with a specific reduction in activation in the amygdala, the midbrain regions, and the dorsal striatum in subjects receiving oxytocin, suggesting that neural systems mediating fear processing (amygdala and midbrain regions) and behavioral adaptations to feedback information (dorsal striatum) modulate oxytocin's effect on trust. These findings may help to develop deeper insights into mental disorders such as social phobia and autism, which are characterized by persistent fear or avoidance of social interactions.