Copper-Catalyzed Amination of Primary Benzylic C-H Bonds with Primary and Secondary Sulfonamides
Copper-Catalyzed Amination of Primary Benzylic C-H Bonds with Primary and Secondary Sulfonamides
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DOI：
10.1021/jo100197r
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发表时间：
2010-04-16
影响因子：
3.6
通讯作者：
Fan, Hope
中科院分区：
文献类型：
--
作者：
Powell, David A.;Fan, Hope
本文介绍了伯磺酰胺和仲磺酰胺在室温下，在铜的催化下，与伯磺酰胺和仲磺酰胺的伯苄基C-H键的胺化反应。该反应适用于一系列伯基和仲基苯基碳氢化合物与多种磺胺类化合物的偶联，并且对偶联对双方的取代都是容忍的。考察了影响主次位C-H官能化选择性的因素。
A room-temperature, copper-catalyzed amination of primary benzylic C-H bonds with primary and secondary sulfonamides is described. The reaction is applicable to the coupling of a range of primary and secondary benzylic hydrocarbons with a diverse set of sulfonamides and is tolerant of substitution on both coupling partners. Factors which influence the selectivity of C-H functionalization between primary and secondary sites are examined.