Tumoral prostate shows different expression pattern of somatostatin receptor 2 (SSTR2) and phosphotyrosine phosphatase SHP-1 (PTPN6) according to tumor progression.
Tumoral prostate shows different expression pattern of somatostatin receptor 2 (SSTR2) and phosphotyrosine phosphatase SHP-1 (PTPN6) according to tumor progression.
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DOI：
10.1155/2009/723831
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发表时间：
2009
影响因子：
1.4
通讯作者：
Zapata PD
中科院分区：
文献类型：
--
作者：
Cariaga-Martinez AE;Lorenzati MA;Riera MA;Cubilla MA;De La Rossa A;Giorgio EM;Tiscornia MM;Gimenez EM;Rojas ME;Chaneton BJ;Rodríguez DI;Zapata PD
前列腺增生依赖于雄激素和许多肽类激素。最近的研究表明SSTR 2和SHP-1是生长抑素抗增殖作用的两个基本成分。对SHP-1的许多研究表明，在所检查的几种癌细胞系和组织中，这种蛋白质的表达减少或消失。然而，有必要将细胞系数据与癌症病例中的真实的情况进行比较。我们的研究表明，在正常和良性增生的上皮表达的两种蛋白质，SHP-1和SSTR 2，定位于管腔侧的导管和腺泡细胞。此外，SSTR 2在基质细胞中表达。在恶性前列腺组织中，SHP-1在28/45例中减少或在12/45例中缺失，而SSTR 2上皮在38/45例中减少或仅在2/45例中缺失。免疫组化染色强度与Gleason分级呈高度负相关。
Prostate proliferation is dependent of androgens and many peptide hormones. Recent reports suggest that SSTR2 and SHP-1 were two fundamental components on antiproliferative effect of somatostatin. Many studies on SHP-1 revealed that the expression of this protein was diminished or abolished in several of the cancer cell lines and tissues examined. However, it is necessary to confront the cell lines data with real situation in cancer cases. Our studies have shown that epithelial expressions of both proteins, SHP-1 and SSTR2, in normal and benign hyperplasia are localized in the luminal side of duct and acinar cells. Also, SSTR2 is expressed in stromal cells. In malignant prostate tissue, SHP-1 was diminished in 28/45 cases or absent in 12/45 cases, whereas SSTR2 epithelial was diminished in 38/45 cases or lost in only 2/45 cases. The intensity of immunostained was highly negative correlated with Gleason grade for two proteins.
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DOI：
10.1084/jem.186.9.1575
发表时间：
1997-11-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Delibrias CC;Floettmann JE;Rowe M;Fearon DT
通讯作者：
Fearon DT
影响因子：
4.1
作者：
Bedecs, K;Elbaz, N;Nahmias, C
通讯作者：
Nahmias, C
影响因子：
--
作者：
Ferjoux, G;Bousquet, C;Susini, C
通讯作者：
Susini, C
影响因子：
11.4
作者：
Bruecher-Encke, B;Griffin, JD;Lorenz, U
通讯作者：
Lorenz, U
影响因子：
4.8
作者：
Lopez, F;Esteve, JP;Susini, C
通讯作者：
Susini, C