Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1
Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1
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DOI：
10.1016/j.jff.2018.09.030
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发表时间：
2018-11
影响因子：
5.6
通讯作者：
Xingsheng Shu;Dan-dan Wang;Yingying Zhao;Yanmei Sun;Xiaopeng Hu;Xiao-yan Huang;Jun-hui Zeng;Chen-yang Li;Yan Li;Yong Zeng;Xiaomei Wang;Zhendan He;Y. Ying
中科院分区：
文献类型：
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作者：
Xingsheng Shu;Dan-dan Wang;Yingying Zhao;Yanmei Sun;Xiaopeng Hu;Xiao-yan Huang;Jun-hui Zeng;Chen-yang Li;Yan Li;Yong Zeng;Xiaomei Wang;Zhendan He;Y. Ying
转移是胃癌（GC）的主要特征，导致预后不良。目前迫切需要寻找新的靶向胃癌转移的药物。辣木（M. oleifera）因其营养和药用价值而长期被公众用作食品。然而，其抗胃癌转移潜能尚不清楚。这里，我们证明了m的残数。油菜花（MO）可以在较低剂量下特异性抑制胃癌细胞的转移，至少部分通过逆转上皮-间质转化（EMT）。此外，rna测序分析显示，骨转移抑制因子NDRG1在MO治疗后显著上调。短干扰RNA敲低NDRG1可显著减弱MO在胃癌细胞中的抗转移作用。因此，我们证明了MO通过增加转移抑制因子NDRG1来抑制emt介导的胃癌转移。我们的研究结果也说明了MO在治疗胃癌转移中的潜在治疗意义。
Metastasis is the major feature of gastric cancer (GC) that contributes to poor prognosis. There is an urgent need to identify novel agents targeting GC metastasis.Moringa oleiferaLam (M. oleifera) has long been used by the public as foods for its nutritional and medicinal virtues. However, its anti-metastatic potential against GC remains unknown. Here, we showed that residues ofM. oleifera(MO) can specifically suppress metastasis of GC cells at a lower dosage, at least partially through reversing the epithelial-mesenchymal transition (EMT). Furthermore, RNA-sequencing analysis revealed that abona fidemetastasis suppressor,NDRG1, was significantly upregulated by MO treatment. Knockdown of NDRG1 by a short interfering RNA dramatically attenuated the anti-metastasis effect of MO in GC cells. Thus, we demonstrate that MO suppresses EMT-mediated metastasis of GC by augmenting the metastatic suppressor NDRG1. Our findings also address the potential therapeutic significance of MO in the treatment of GC metastasis.