Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence.
Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence.
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DOI：
10.1152/ajpendo.2001.280.1.e120
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
F. Coppenolle;Christian Slomianny;Françoise Carpentier;X. Bourhis;Ahmed Ahidouch;D. Croix;Guillaume Legrand;E. Dewailly;Sarah Fournier;Henri Cousse;Dominique Authie;Jean-Pierre Raynaud;J. Beauvillain;Jean-Paul Dupouy;Natalia Prevarskaya
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作者：
F. Coppenolle;Christian Slomianny;Françoise Carpentier;X. Bourhis;Ahmed Ahidouch;D. Croix;Guillaume Legrand;E. Dewailly;Sarah Fournier;Henri Cousse;Dominique Authie;Jean-Pierre Raynaud;J. Beauvillain;Jean-Paul Dupouy;Natalia Prevarskaya
多肽激素催乳素（PRL）在良性前列腺增生（BPH）和前列腺癌的发展和调节中的作用还没有得到很好的表征。本研究检查了PRL单独或与雄激素[睾酮（T）或双氢睾酮（DHT）]联合在大鼠前列腺中的作用。PRL和雄激素的影响进行了研究后30和60天的控制，阉割，阉割与替代植入物的T或DHT，和假手术Wistar大鼠。为了增强PRL的释放，我们通过长期注射舒必利（40 mg. kg（-1）。天（-1））。慢性高催乳素血症诱导大鼠前列腺外侧叶增大和炎症，腹叶和背叶无任何组织学变化。我们还表明，高催乳素血症诱导Bcl-2的过度表达，在侧大鼠前列腺，这可能会抑制细胞凋亡的水平。在这里建立的体内模型是一个有用的在体内研究正常和病理性前列腺发育的激素调节的方法。
The effects of the polypeptide hormone prolactin (PRL) in the development and regulation of benign prostate hyperplasia (BPH) and also in prostate cancer are not very well characterized. This study examines the action of PRL, either alone or in association with androgens [testosterone (T) or dihydrotestosterone (DHT)], in the rat prostate gland. The effects of PRL and androgens were investigated after 30 and 60 days in control, castrated, castrated with a substitutive implant of T or DHT, and sham-operated Wistar rats. To enhance PRL release, we induced hyperprolactinemia by administering chronic injections of sulpiride (40 mg. kg(-1). day(-1)). Chronic hyperprolactinemia induces enlargement and inflammation of the lateral rat prostate without any histological changes on ventral and dorsal lobes. We also demonstrate that hyperprolactinemia induces Bcl-2 overexpression in the lateral rat prostate and that this could inhibit the level of apoptosis. The in vivo model established here is a useful in vivo approach for studying the hormonal regulation of normal and pathological prostate development.