Effect of imipramine treatment on the prolactin response to fenfluramine and placebo challenge in depressed patients.
Effect of imipramine treatment on the prolactin response to fenfluramine and placebo challenge in depressed patients.
复制标题
丙咪嗪治疗对抑郁症患者催乳素对芬氟拉明和安慰剂挑战的反应的影响。
DOI：
10.1016/0165-0327(89)90047-5
复制
发表时间：
1989
影响因子：
6.6
通讯作者：
Lerer,B
中科院分区：
文献类型：
--
作者：
Shapira,B;Reiss,A;Kaiser,N;Kindler,S;Lerer,B
10例抑郁症患者用丙咪嗪200 mg/d治疗3周，观察其对芬氟拉明（60 mg口服）和安慰剂激发的血浆催乳素反应，作为中枢神经系统功能的指标。尽管丙咪嗪没有改变基线催乳素水平，但与未治疗状态下的反应相比，对芬氟拉明的催乳素反应显着增加（P= 0.01）。对安慰剂的反应也增强了，但这种作用的程度较小，没有统计学意义。这些研究结果补充了以前的报告，并表明三环类抗抑郁药治疗增强神经内分泌介导的神经内分泌反应。
As an index of central serotonergic function, plasma prolactin response to fenfluramine (60 mg orally) and placebo challenge was examined in 10 depressed patients before and after treatment with imipramine 200 mg/day for 3 weeks. Although baseline prolactin levels were not altered by imipramine, the prolactin response to fenfluramine was significantly (P= 0.01) increased compared to the response in the untreated state. The response to placebo was also enhanced but this effect was of lesser magnitude and not statistically significant. These findings complement previous reports and suggest that tricyclic antidepressant treatment enhances serotonergically mediated neuroendocrine responses.