Baseline delayed verbal recall predicts response to high definition transcranial direct current stimulation targeting the superior medial frontal cortex
Baseline delayed verbal recall predicts response to high definition transcranial direct current stimulation targeting the superior medial frontal cortex
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DOI：
10.1016/j.neulet.2021.136204
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发表时间：
2021-09-04
影响因子：
2.5
通讯作者：
Hart, John Jr Jr
中科院分区：
文献类型：
--
作者：
Chiang, Hsueh-Sheng;Motes, Michael;Hart, John Jr Jr
靶向前补充运动区/背侧前扣带皮层（pre-SMA/dACC）的阳极高清晰度经颅直流电刺激（HD-tDCS）最近已显示出改善患有慢性创伤性脑损伤（TBI）的退伍军人的言语检索缺陷（Motes等人，2020），但治疗反应的预测因素尚不清楚。我们假设，基线延迟言语回忆，TBI后慢性认知下降的敏感指标，将预测HD-tDCS靶向SMA/dACC前体的言语检索缺陷的治疗效果。在基线、治疗结束后即刻和治疗结束后8周进行标准化语言检索测量。我们采用混合广义线性模型作为事后分组分析的口头检索分数，表现出显着的改善，在微尘。（2020），以检查与假手术组（N = 7）相比，基线完整延迟回忆（N = 10）和基线受损延迟回忆（N = 8）组中主动刺激的效果。基线延迟回忆受损的个体在类别流畅性和颜色词抑制/转换方面都有显着改善（与基线相比），而延迟回忆完整的个体仅在颜色词抑制/转换方面有显着改善。因此，基线延迟言语回忆可以被认为是未来针对额叶结构的电调制研究的预测因子，以治疗TBI相关的言语缺陷。
Anodal high definition transcranial direct current stimulation (HD-tDCS) targeting the pre-supplementary motor area/dorsal anterior cingulate cortex (pre-SMA/dACC) has recently been shown to improve verbal retrieval deficits in veterans with chronic traumatic brain injury (TBI) (Motes et al., 2020), but predictors of treatment response are unclear. We hypothesized that baseline delayed verbal recall, a sensitive measure for post-TBI chronic cognitive decline, would predict therapeutic effects of HD-tDCS targeting the pre-SMA/dACC for verbal retrieval deficits. Standardized verbal retrieval measures were administered at baseline, immediately after and 8 weeks after treatment completion. We applied mixed generalized linear modeling as a post-hoc subgroup analysis to the verbal retrieval scores that showed significant improvement in Motes at el. (2020) to examine effects of active stimulation across the groups with baseline-intact delayed recall (N = 10) and baseline-impaired delayed recall (N = 8), compared to sham (N = 7). Individuals with impaired baseline delayed recall showed significant improvement (compared to baseline) in both category fluency and color-word inhibition/switch, while individuals with intact delayed recall showed significant improvement only in color-word inhibition/switch. Baseline delayed verbal recall may therefore be considered as a predictor for future electromodulation studies targeting frontal structures to treat TBI-related verbal deficits.