HUMAN AND DROSOPHILA HOMEODOMAIN PROTEINS THAT ENHANCE THE DNA-BINDING ACTIVITY OF SERUM RESPONSE FACTOR
HUMAN AND DROSOPHILA HOMEODOMAIN PROTEINS THAT ENHANCE THE DNA-BINDING ACTIVITY OF SERUM RESPONSE FACTOR
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DOI：
10.1126/science.257.5073.1089
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发表时间：
1992-08-21
期刊：
影响因子：
56.9
通讯作者：
GILMAN, MZ
中科院分区：
文献类型：
--
作者：
GRUENEBERG, DA;NATESAN, S;GILMAN, MZ
具有不同发育历史的细胞可以对相同的信号做出不同的反应，这表明信号以一种反映细胞身份的方式被解释。这可能是通过观察同源结构域家族的蛋白质，包括一种新发现的人类蛋白质，增强血清反应因子的dna结合活性提出的，血清反应因子是生长和分化因子诱导基因所需的蛋白质。与血清反应因子家族蛋白的相互作用可能允许同源结构域蛋白指定对诱导信号的转录反应。此外，由于增强血清反应因子与DNA结合的能力存在于同位结构域内，但与同位结构域DNA结合活性无关，因此同位结构域的这种额外活性可能解释了同位结构域蛋白在发育过程中的一些特异性作用。
Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development.