Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population.
Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population.
复制标题
DOI：
10.1002/cncr.24289
复制
发表时间：
2009-06-15
期刊：
影响因子：
6.2
通讯作者：
Shu, Xiao-Ou
中科院分区：
文献类型：
--
作者：
Xu, Wang-Hong;Long, Ji-rong;Zheng, Wei;Ruan, Zhi-xian;Cai, Qiuyin;Cheng, Jia-rong;Xiang, Yong-Bing;Shu, Xiao-Ou
孕激素受体（PGR）基因的单核苷酸多态性（SNP）与子宫内膜癌的风险有关。然而，没有研究系统地评估PGR基因在子宫内膜癌发生中的作用。本研究使用了上海子宫内膜癌研究中收集的暴露信息和DNA样本，该研究是一项基于人群的病例对照研究，包括1，204例发病病例和1，212例年龄频率匹配的人群对照。使用来自HapMap项目的中国汉族数据，在PCR基因加5 kb侧翼区鉴定出7个标签SNP，成对r2 ≥ 0.90。这7个SNP捕获了该区域中92%的成对r2 ≥ 0.90的SNP或100%的成对r2 ≥ 0.80的SNP。使用Affyssin MegAllele靶向基因分型系统进行多态性的基因分型。采用逻辑回归模型计算调整后的比值比（OR）和95%置信区间（CI）。在评估的7个标签SNPs中，PGR基因3'侧翼区的两个多态性rs 11224561和rs 471767与子宫内膜癌的风险相关。与TT基因型相比，SNP rs 11224561基因型CC与风险降低相关（OR=0.68，95%CI =0.50-0.92）。携带rs 471767 SNP的G等位基因也与风险降低相关，尽管这种相关性没有统计学意义（与纯合子AA相比，AG和GG基因型的OR分别为0.78，95%CI=0.59-1.04和0.32，95%CI=0.03-3.05）。我们的研究结果表明，PGR基因3'侧翼区的多态性可能与子宫内膜癌的风险有关。
Single nucleotide polymorphisms (SNPs) in the progesterone receptor (PGR) gene have been associated with the risk of endometrial cancer. However, no study has systematically evaluated the role of the PGR gene in endometrial carcinogenesis. Exposure information and DNA samples collected in the Shanghai Endometrial Cancer Study, a population-based case-control study of 1,204 incident cases and 1,212 age frequency-matched population controls, were used in this study. Seven tag SNPs were identified for the PGR gene plus the 5 kb flanking regions using the Han Chinese data from the HapMap project with a pairwise r2 ≥ 0.90. These 7 SNPs captured 92% of SNPs in the region with a pairwise r2 ≥ 0.90 or 100% of SNPs with a pairwise r2 ≥ 0.80. Genotyping of polymorphisms was performed by using the Affymetrix MegAllele Targeted Genotyping System. A logistic regression model was employed to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Of seven tag SNPs assessed, two polymorphisms in the 3’ flanking region of the PGR gene, rs11224561 and rs471767, were associated with the risk of endometrial cancer. Genotype CC of SNP rs11224561 was associated with decreased risk (OR=0.68, 95% CI=0.50-0.92) compared to the TT genotype. Carrying the G allele of the rs471767 SNP was also associated with decreased risk, although the association was not statistically significant (OR=0.78, 95%CI=0.59-1.04 and OR=0.32, 95%CI=0.03-3.05 for the AG and GG genotypes, respectively, compared with the homozygote AA). Our findings suggest that polymorphisms in the 3’ flanking region of the PGR gene may be associated with the risk of endometrial cancer.
登录
查看更多内容
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
64.5
作者：
VEGETO, E;ALLAN, GF;OMALLEY, BW
通讯作者：
OMALLEY, BW
影响因子：
2.1
作者：
Lin, DY;Zeng, D;Millikan, R
通讯作者：
Millikan, R
影响因子：
11.4
作者：
KASTNER, P;KRUST, A;CHAMBON, P
通讯作者：
CHAMBON, P
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D