The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon.
The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon.
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根据生物操纵子的核苷酸序列预测大肠杆菌生物素生物合成酶序列。
DOI：
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发表时间：
1988
影响因子：
4.8
通讯作者：
Junichi Matsuzakii
中科院分区：
文献类型：
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作者：
Anthony J. OtsukaS;Martin R. Buoncristiani;Peter K. Howard;Jason Flamm;Christopher Johnson;Robert Yamamoto;Kevin Uchida;Charles Cook;James Ruppert;Junichi Matsuzakii
大肠杆菌生物素（bio）生物合成操作子的核苷酸序列已经确定。该 5.8 千碱基区域包含五个生物素操作子基因 bioA、B、F、C 和 D，以及一个功能未知的开放阅读框。该操作子受负调控，并从 bioA 和 bioB 基因之间的控制区进行分化转录。生物 A 基因的产物 7,8-二氨基壬二酸氨基转移酶被发现与鸟氨酸氨基转移酶有关。生物 F 基因的产物 7-酮-8-氨基壬二酸合成酶与 5-氨基乙酰丙酸合成酶相似。
The nucleotide sequence of the biotin (bio) biosynthetic operon of Escherichia coli has been determined. The 5.8-kilobase region contains the five biotin operon genes, bioA, B, F, C, and D. and an open reading frame of unknown function. The operon is negatively regulated and divergently transcribed from a control region between the bioA and bioB genes. The product of the bioA gene, 7,8-diaminopelargonic acid aminotransferase, was discovered to be related to ornithine aminotransferase. The product of the bioF gene, 7-keto-8-aminopelargonic acid synthetase, was found to be similar to 5-aminolevulinic acid synthetase.