MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and III
MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and III
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DOI：
10.1101/cshperspect.a018408
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发表时间：
2014-05-01
影响因子：
5.4
通讯作者：
White, Robert J.
中科院分区：
文献类型：
--
作者：
Campbell, Kirsteen J.;White, Robert J.
MYC的致瘤潜力涉及增加的核糖体生物合成和翻译能力，这为细胞提供了增强细胞生长和随后细胞分裂所需的蛋白质。除了激活由RNA聚合酶II转录的蛋白质编码基因外，MYC还必须刺激RNA聚合酶I和RNA聚合酶III的转录以满足这种合成需求。在过去的十年中，我们对MYC调控RNA聚合酶I和III的机制和重要性的认识蓬勃发展。在这里，我们讨论了MYC对这些“奇怪的”RNA聚合酶转录的影响，并评估了这种调节对癌症发展和治疗的生理影响。
MYC's tumorigenic potential involves increased ribosome biogenesis and translational capacity, which supply the cell with protein required for enhanced cell growth and subsequent cell division. In addition to activation of protein-encoding genes transcribed by RNA polymerase II, MYC must stimulate transcription by RNA polymerase I and RNA polymerase III to meet this synthetic demand. In the past decade our knowledge of the mechanisms and importance of MYC regulation of RNA polymerases I and III has flourished. Here we discuss MYC's influence on transcription by these "odd" RNA polymerases and the physiological impact of this regulation is evaluated with relevance to cancer development and treatment.