Preconception paternal mental disorders and child health: Mechanisms and interventions
Preconception paternal mental disorders and child health: Mechanisms and interventions
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DOI：
10.1016/j.neubiorev.2022.104976
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发表时间：
2022-11
影响因子：
8.2
通讯作者：
Xia Tan;Jingwen Luo;Xiaofang Ding;Honggang Li
中科院分区：
文献类型：
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作者：
Xia Tan;Jingwen Luo;Xiaofang Ding;Honggang Li
精神疾病是一个重大的全球健康问题，患病率稳定。人们怀疑其具有高遗传性，但全基因组关联研究仅发现了少数与精神障碍相关的风险基因。这种“缺失的遗传”可以部分地用表观遗传来解释。来自大量动物模型和人类研究的证据支持这样一种可能性：先入为主的父亲心理健康通过非遗传手段影响后代的心理健康。在这里，我们回顾了两种潜在的途径，包括精子表观遗传学和精浆成分。当前的综述强调了精子表观遗传学的作用，并探讨了表观遗传信息的起源和对慢性压力的敏感性。同时，本综述还推断了可能诱发性别二态模式的时空窗口和事件以及父本压力传递的影响。此外，我们还讨论了可能阻止父亲精神疾病代际传播并降低精神疾病发病率的新兴干预措施。了解孕前父亲压力影响后代健康的潜在机制对于确定支持健康发展和成功控制精神疾病患病率的策略至关重要。
Mental illness is a significant global health issue with a steady prevalence. High heritability is suspected, but genome-wide association studies only identified a small number of risk genes associated with mental disorders. This ‘missing inheritance’ can be partially explained by epigenetic heredity. Evidence from numerous animal models and human studies supports the possibility that preconception paternal mental health influences their offspring’s mental health via nongenetic means. Here, we review two potential pathways, including sperm epigenetics and seminal plasma components. The current review highlights the role of sperm epigenetics and explores epigenetic message origination and susceptibility to chronic stress. Meanwhile, possible spatiotemporal windows and events that induce sexually dimorphic modes and effects of paternal stress transmission are inferred in this review. Additionally, we discuss emerging interventions that could potentially block the intergenerational transmission of paternal psychiatric disorders and reduce the incidence of mental illness. Understanding the underlying mechanisms by which preconception paternal stress impacts offspring health is critical for identifying strategies supporting healthy development and successfully controlling the prevalence of mental illness.