Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study
Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study
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DOI：
10.1097/01.wnr.0000224769.92454.5d
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发表时间：
2006-07-17
期刊：
影响因子：
1.7
通讯作者：
Wang, Yufeng
中科院分区：
文献类型：
--
作者：
Cao, Qingjiu;Zang, Yufeng;Wang, Yufeng
在这项研究中，采用了一种新报道的局部一致性方法来分析注意缺陷多动障碍男孩静息态血氧水平依赖性功能磁共振成像数据。注意缺陷多动障碍男孩在额 - 纹状体 - 小脑回路中局部一致性降低，但主要在枕叶皮质局部一致性增加。我们的研究结果与注意缺陷多动障碍中额 - 纹状体 - 小脑回路异常的假说相符。局部一致性方法可能是探索注意缺陷多动障碍病理生理学的一种潜在有用的方法。
In this study, a newly reported regional homogeneity approach was used to analyze blood oxygen level-dependent functional magnetic resonance imaging data on resting state in boys with attention deficit hyperactivity disorder. Boys with attention deficit hyperactivity disorder showed decreased regional homogeneity in the frontal-striatal-cerebellar circuits, but increased regional homogeneity mainly in the occipital cortex. Our findings are consistent with the hypothesis of abnormal frontal-striatal-cerebellar circuits in attention deficit hyperactivity disorder. The regional homogeneity approach may be a potentially useful method in exploring the pathophysiology of attention deficit hyperactivity disorder.