Associations between bone mineral density and urinary phthalate metabolites among post-menopausal women: a cross-sectional study of NHANES data 2005-2010
Associations between bone mineral density and urinary phthalate metabolites among post-menopausal women: a cross-sectional study of NHANES data 2005-2010
复制标题
DOI：
10.1080/09603123.2015.1111312
复制
发表时间：
2016-05-03
影响因子：
3.2
通讯作者：
Turyk, Mary E.
中科院分区：
文献类型：
--
作者：
DeFlorio-Barker, Stephanie A.;Turyk, Mary E.
骨矿物质密度（BMD）随着年龄的增长而下降，尤其是在绝经后妇女中。暴露于内分泌干扰物，如邻苯二甲酸二酯，可能会通过各种未知的机制改变BMD。一项产生假设的研究调查了2005年至2010年参加国家健康和营养检查调查的绝经后妇女（n=480）的尿邻苯二甲酸酯代谢物与股骨颈和脊柱BMD之间的相关性。邻苯二甲酸单乙酯（MEP）、低分子量代谢物（邻苯二甲酸单正丁酯（MNBP）、邻苯二甲酸单异丁酯（MIBP）、MEP）的摩尔总和、雌激素代谢物（MNBP、MIBP、MEP、邻苯二甲酸单苄酯（MBZP））的摩尔总和以及雌激素等效因子与脊柱BMD呈负相关。一些关联被年龄或BMI修改。横断面研究设计、暴露关键时间窗的不确定性、暴露错误分类的可能性和残留混杂因素限制了我们得出关于绝经后女性中邻苯二甲酸酯代谢物和BMD的因果关系结论的能力。未来的研究应该解决这些局限性。
Bone mineral density (BMD) decreases with age, especially among post-menopausal women. Exposures to endocrine disruptors, such as phthalate diesters, could alter BMD through a variety of unidentified mechanisms. A hypothesis-generating study investigated associations between urinary phthalate metabolites and BMD at the femoral neck and spine in post-menopausal women (n=480) participating in the National Health and Nutrition Examination Survey, from 2005 to 2010. Mono-ethyl phthalate (MEP), molar sum of low molecular weight metabolites (mono-n-butyl phthalate (MNBP), mono-isobutyl phthalate (MIBP), MEP), molar sum of estrogenic metabolites (MNBP, MIBP, MEP, mono-benzyl phthalate (MBZP)), and an estrogenic equivalency factor were negatively associated with spinal BMD. Some associations were modified by age or BMI. The cross-sectional study design, uncertainty regarding the critical time window of exposure, the potential for exposure misclassification, and residual confounding limit our abilities to draw causal conclusions regarding phthalate metabolites and BMD in post-menopausal women. Future studies should address these limitations.