Simple and Generalized Synthesis of Oxide-Metal Heterostructured Nanoparticles and their Applications in Multimodal Biomedical Probes
Simple and Generalized Synthesis of Oxide-Metal Heterostructured Nanoparticles and their Applications in Multimodal Biomedical Probes
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DOI：
10.1021/ja805311x
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发表时间：
2008-11-19
影响因子：
15
通讯作者：
Hyeon, Taeghwan
中科院分区：
文献类型：
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作者：
Choi, Sang-Hyun;Na, Hyon Bin;Hyeon, Taeghwan
通过金属-油酸盐络合物(氧化物组分)和金属-油胺络合物(金属组分)的混合热分解，合成了由金属和Fe3O4或MnO组成的异质结构纳米颗粒。产物包括花状的铂-Fe3O4和Ni-Fe3O4纳米颗粒以及雪人状的Ag-MnO和Au-MnO纳米颗粒。粉末X射线衍射图表明，这些纳米粒子是由面心立方(FCC)结构的Fe3O4或MnO和FCC结构的金属组成。Au-MnO和Au-Fe3O4纳米粒子的弛豫值分别与MnO和Fe3O4纳米粒子相近。与两种12碱基寡核苷酸序列偶联的Au-Fe3O4异质结构纳米粒子能够感知互补的24聚体序列，导致纳米粒子聚集。通过动态光散射数据显示的整体尺寸增大、Au组分的表面等离子激元带的红移以及T-2加权磁共振成像中Fe3O4组分的信号强度的增强，可以检测到这种杂交介导的聚集。
Heterostructured nanoparticles composed of metals and Fe3O4 or MnO were synthesized by thermal decomposition of mixtures of metal-oleate complexes (for the oxide component) and metal-oleylamine complexes (for the metal component). The products included flowerlike-shaped nanoparticles of Pt-Fe3O4 and Ni-Fe3O4 and snowmanlike-shaped nanoparticles of Ag-MnO and Au-MnO. Powder X-ray diffraction patterns showed that these nanoparticles were composed of face-centered cubic (fcc)-structured Fe3O4 or MnO and fcc-structured metals. The relaxivity values of the Au-MnO and Au-Fe3O4 nanoparticles were similar to those of the MnO and Fe3O4 nanoparticles, respectively. Au-Fe3O4 heterostructured nanoparticles conjugated with two kinds of 12-base oligonucleotide sequences were able to sense a complementary 24-mer sequence, causing nanoparticle aggregation. This hybridization-mediated aggregation was detected by the overall size increase indicated by dynamic light scattering data, the red shift of the surface plasmon band of the Au component, and the enhancement of the signal intensity of the Fe3O4 component in T-2-weighted magnetic resonance imaging.