Isolation and Characterization of Peritoneal Macrophages from Salamanders.
Isolation and Characterization of Peritoneal Macrophages from Salamanders.
复制标题
蝾螈腹膜巨噬细胞的分离和表征。
DOI：
10.1007/978-1-0716-2659-7_18
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
DelRio-Tsonis,Katia
中科院分区：
文献类型：
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作者：
Sallese,Anthony;Tsissios,Georgios;Pérez-Estrada,JRaúl;Martinez,Arielle;DelRio-Tsonis,Katia
蝾螈被用作研究模型已经有几个世纪了。虽然它们表现出哺乳动物所没有的广泛的生物学特征，但没有一个像它们的再生能力那样吸引科学家。有趣的是，蝾螈巨噬细胞已经成为组织再生的重要细胞群体。其他蝾螈，如绿背蝾螈、红腹蝾螈或拟蝾螈，是否也是如此，还有待观察。不幸的是，无论种类如何，研究蝾螈巨噬细胞功能的分子工具都缺乏。我们建议，可用于验证分子试剂在蝾螈组织再生过程中的巨噬细胞功能的研究，从蝾螈或蝾螈的终末分化的腹腔巨噬细胞。
Salamanders have been used as research models for centuries. While they exhibit a wide range of biological features not seen in mammals, none has captivated scientists like their ability to regenerate. Interestingly, axolotl macrophages have emerged as an essential cell population for tissue regeneration. Whether the same is true in other salamanders such as newt speciesNotophthalmus viridescens,Cynops pyrrhogaster, orPleurodeles waltlremains to be seen. Unfortunately, regardless of the species, molecular tools to study macrophage function in salamanders are lacking. We propose that the readily available, terminally differentiated peritoneal macrophages from newts or axolotls could be used to validate molecular reagents in the study of macrophage function during tissue regeneration in salamanders.