Short-term interferon-alfa therapy for acute hepatitis C: A randomized controlled trial
Short-term interferon-alfa therapy for acute hepatitis C: A randomized controlled trial
复制标题
DOI：
10.1002/hep.20196
复制
发表时间：
2004-05-01
期刊：
影响因子：
13.5
通讯作者：
Kashiwagi, S
中科院分区：
文献类型：
--
作者：
Nomura, H;Sou, S;Kashiwagi, S
急性丙型肝炎通常进展为慢性感染。我们进行了一项随机对照试验，以确定在急性丙型肝炎期间使用干扰素(干扰素)短期治疗是否有效预防慢性肝炎的发展。将30例急性丙型肝炎患者随机分为2组。早期干预组在急性肝炎发病8周后开始干扰素治疗，晚期干预组在观察1年后开始干扰素治疗。短期治疗包括自然干扰素-α(600万单位)，连续4天给药，疗程4周。任何疾病复发的迹象都立即进行间隔干扰素治疗(每周3次，持续20周)。在早期干预组中，15名患者中有13名(87%)的短期治疗与持续的病毒学应答有关。在其余两名患者中，随访治疗与持续的病毒学应答有关(100%)。早期干预组持续病毒学应答率(87%，15例单纯短期治疗后13例，100%，15例短期治疗后有无随访)显著高于晚期干预组(40%，15例单纯短期治疗后6例，短期治疗后8例，P=0.021，P=0.006)。总之，如果在疾病的早期阶段开始，对急性丙型肝炎患者进行短期(4周)的干扰素治疗可能会获得令人满意的结果。
Acute hepatitis C often progresses to chronic infection. We undertook a randomized controlled trial to determine whether short-term therapy with interferon (IFN) during acute hepatitis C is effective in preventing the development of chronic hepatitis. Thirty patients with acute hepatitis C were randomized into 1 of 2 treatment groups. IFN therapy was initiated 8 weeks after the onset of acute hepatitis in the early-intervention group and after I year of observation in the late-intervention group. Short-term therapy consisted of natural IFN-alfa (6 million units) administered on consecutive days for a period of 4 weeks. Any signs of recrudescence of disease were immediately followed by interval IFN therapy (3 times weekly for 20 weeks). In the early-intervention group, short-term therapy was associated with a sustained virological response in 13 of 15 patients (87%). Follow-up treatment was associated with a sustained virological response in both of the remaining 2 patients (100%). The sustained virological response rate was significantly higher in the early-intervention group (87%, 13 of 15 patients after short-term therapy alone, and 100%, 15 of 15 patients after short-term with or without follow-up therapy) than in the late-intervention group (40%, 6 of 15 patients after short-term therapy alone, and 53%, 8 of 15 patients after short-term therapy with or without follow-up therapy, P = .021 and P = .006, respectively). In conclusion, short-term (4 weeks) IFN treatment of patients with acute hepatitis C may be associated with satisfactory results, if initiated at an early stage of the disease.