Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
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DOI：
10.1016/j.chom.2012.04.016
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发表时间：
2012-06-14
影响因子：
30.3
通讯作者：
Oldstone MB
中科院分区：
文献类型：
--
作者：
Walsh KB;Teijaro JR;Zuniga EI;Welch MJ;Fremgen DM;Blackburn SD;von Tiehl KF;Wherry EJ;Flavell RA;Oldstone MB
TLR 7是一种识别单链病毒RNA的先天信号受体，并被导致持续感染的病毒激活。我们表明，TLR 7信号传导决定淋巴细胞性脉络丛脑膜炎病毒（LCMV）C113的终身慢性感染的清除或建立，但不影响急性LCMV Armstrong 53 b株的清除。感染LCMV Cl 13的TLR 7 −/−小鼠由于适应性抗病毒免疫应答的缺陷而终生保持病毒血症，特别是T细胞功能减弱，T细胞耗竭加剧，浆细胞成熟减少，抗病毒抗体产生可忽略不计。增强TLR 7 +/+小鼠中持续性LCMV C113感染清除的TLR 7 +/+ LCMV免疫记忆细胞的连续转移不能清除TLR 7-/-小鼠中的LCMV C113感染，表明TLR 7缺陷环境使抗病毒应答无效。因此，促进TLR 7信号传导的方法是慢性病毒感染的有希望的治疗策略。
TLR7 is an innate signaling receptor that recognizes single-stranded viral RNA and is activated by viruses that cause persistent infections. We show that TLR7 signaling dictates either clearance or establishment of life-long chronic infection by lymphocytic choriomeningitis virus (LCMV) Cl 13 but does not affect clearance of the acute LCMV Armstrong 53b strain. TLR7−/− mice infected with LCMV Cl 13 remained viremic throughout life from defects in the adaptive anti-viral immune response, notably diminished T cell function, exacerbated T cell exhaustion, decreased plasma cell maturation, and negligible anti-viral antibody production. Adoptive transfer of TLR7+/+ LCMV immune memory cells that enhance clearance of persistent LCMV Cl 13 infection in TLR7+/+ mice fail to purge LCMV Cl 13 infection in TLR7−/− mice, demonstrating that a TLR7-deficient environment renders anti-viral responses ineffective. Therefore, methods that promote TLR7 signaling are promising treatment strategies for chronic viral infections.
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影响因子：
5.4
作者：
BORROW, P;EVANS, CF;OLDSTONE, MBA
通讯作者：
OLDSTONE, MBA
影响因子：
4.4
作者：
Heer, Alex K.;Shamshiev, Abdijapar;Marsland, Benjamin J.
通讯作者：
Marsland, Benjamin J.
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John
DOI：
10.1084/jem.20050821
发表时间：
2005-09-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kolumam GA;Thomas S;Thompson LJ;Sprent J;Murali-Krishna K
通讯作者：
Murali-Krishna K
影响因子：
6.7
作者：
Browne EP
通讯作者：
Browne EP