Quantified Brain Magnetic Resonance Imaging Volumes Differentiate Behavioral Variant Frontotemporal Dementia from Early-Onset Alzheimer's Disease.
Quantified Brain Magnetic Resonance Imaging Volumes Differentiate Behavioral Variant Frontotemporal Dementia from Early-Onset Alzheimer's Disease.
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DOI：
10.3233/jad-215667
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发表时间：
2022
影响因子：
4
通讯作者：
Mendez, Mario F.
中科院分区：
文献类型：
--
作者：
Meysami, Somayeh;Raji, Cyrus A.;Mendez, Mario F.
根据临床标准区分行为变异型额颞叶痴呆（bvFTD）和早发性阿尔茨海默病（EOAD）可能不准确。临床上可用的磁共振（MR）脑部扫描的体积量化可能有助于这些神经退行性痴呆的早期诊断。确定脑MR成像的体积定量是否可以识别bvFTD与EOAD患者。使用Neuroreader比较了20例bvFTD患者和45例EOAD患者的3D T1 MR脑部扫描，以测量皮质下和叶体积，以及海马子域的Volbrain。分析包括：1）具有留一交叉验证的判别分析; 2）将来自该过程的预测概率输入到接受者操作者特征（ROC）分析中;以及3）自动线性回归以识别预测区域。两组在年龄和性别上相当，症状持续时间无统计学显著差异。bvFTD在额叶、丘脑和壳核中的体积减少。EOAD的顶叶体积较低。ROC分析显示，Neuroreader扫描仪的准确率为99.3%，子字段的准确率为80.2%。顶叶是最具预测性的百分位数。虽然海马（特别是左CA 2-CA 3）子字段存在差异，但它并没有添加到判别分析中。基于MR的体积定量的百分位数有助于在常规临床治疗中区分bvFTD与EOAD。使用海马子域体积并不能提高这两种早发性痴呆的诊断分离。
The differentiation of behavioral variant frontotemporal dementia (bvFTD) from early-onset Alzheimer’s disease (EOAD) by clinical criteria can be inaccurate. The volumetric quantification of clinically available magnetic resonance (MR) brain scans may facilitate early diagnosis of these neurodegenerative dementias. To determine if volumetric quantification of brain MR imaging can identify persons with bvFTD from EOAD. 3D T1MR brain scans of 20 persons with bvFTD and 45 with EOAD were compared using Neuroreader to measure subcortical, and lobar volumes, and Volbrain for hippocampal subfields. Analyses included: 1) discriminant analysis with leave one out cross-validation; 2) input of predicted probabilities from this process into a receiver operator characteristic (ROC) analysis; and 3) Automated linear regression to identify predictive regions. Both groups were comparable in age and sex with no statistically significant differences in symptom duration. bvFTD had lower volume percentiles in frontal lobes, thalamus, and putamen. EOAD had lower parietal lobe volumes. ROC analyses showed 99.3% accuracy with Neuroreader percentiles and 80.2% with subfields. The parietal lobe was the most predictive percentile. Although there were differences in hippocampal (particularly left CA2-CA3) subfields, it did not add to the discriminant analysis. Percentiles from an MR based volumetric quantification can help differentiate between bvFTD from EOAD in routine clinical care. Use of hippocampal subfield volumes does not enhance the diagnostic separation of these two early-onset dementias.
影响因子：
2
作者：
Han, Yongli;Albert, Paul S.;Berg, Christine D.;Wentzensen, Nicolas;Katki, Hormuzd A.;Liu, Danping
通讯作者：
Liu, Danping