CXXV - Studies of dynamic isomerism - I The mutarotation of glucose
CXXV - Studies of dynamic isomerism - I The mutarotation of glucose
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DOI：
10.1039/ct9038301314
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发表时间：
1903-01-01
期刊：
影响因子：
--
通讯作者：
Lowry, TM
中科院分区：
文献类型：
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作者：
Lowry, TM
1846年，杜布朗方观察到新配制的葡萄糖水溶液的旋光度逐渐变化，起初被认为是纯粹的物理原因。直到1890年埃米尔·费希尔发现旋光能力的类似变化是由旋光活性内酯在水溶液中的部分水解产生的，并提出葡萄糖的变旋可能是由于糖与水结合转化为旋光能力较低的七元醇而引起的，才认识到这一现象的化学特征：
THE gradual change in the rotatory power of freshly prepared aquems solutions of glucose, observed by Dubrunfant in 1846, was at first regarded as being due to purely physical causes. The chemical character of the phenomenon was not recognised until Emil Fischer, in 1890, discovered that similar changes of rotatory power were produced by the partial hydrolysis, in aqueous solution, of optically active lactones and suggested that the mutarotation of glucose might be due to the conversion of the sugar by combination with water into a heptahydric alcohol of lower rotatory power: