PLASMA-CORTISOL IN DEPRESSIVE-ILLNESS
PLASMA-CORTISOL IN DEPRESSIVE-ILLNESS
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DOI：
10.1016/0022-3956(62)90006-7
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发表时间：
1962-01-01
影响因子：
4.8
通讯作者：
MCHUGH, PR
中科院分区：
文献类型：
--
作者：
GIBBONS, JL;MCHUGH, PR
本文对17例抑郁症患者在18个住院期间每周测定一次血浆皮质醇。在治疗前发现皮质醇水平升高，一般来说，抑郁症越严重，皮质醇水平越高。在13个案例中，恢复过程伴随着皮质醇水平的下降。五个案件，未能符合这一模式进行了讨论。详细介绍了一个循环型患者在连续三个周期的抑郁症和轻度抑郁症。建议进一步的工作，以评估抑郁症的肾上腺皮质活动的程度，并确定其生物学的重要性。
Plasma cortisol was measured at weekly intervals in 17 depressed patients during 18 periods of stay in hospital. Elevated levels were found before treatment, and in general the more severe the depression, the higher the cortisol level. In 13 cases the process of recovery was accompanied by a decline in cortisol levels. The five cases that failed to conform to this pattern are discussed. Details are presented of a cyclothymic patient during three successive cycles of depression and mild elation. Suggestions are made for further work to assess the degree of adrenocortical activity in depression and to determine its biological importance.