A PRACTICAL SYNTHESIS OF GLYCINAMIDE RIBONUCLEOTIDE
A PRACTICAL SYNTHESIS OF GLYCINAMIDE RIBONUCLEOTIDE
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DOI：
10.3987/com-18-s(t)50
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发表时间：
2018-09-01
期刊：
影响因子：
0.6
通讯作者：
O'Doherty, George A.
中科院分区：
文献类型：
--
作者：
Ray, Debarpita;Beuning, Penny J.;O'Doherty, George A.
研究了甘氨酸酰胺核糖核苷酸（GAR）的α -/ β -端粒混合物的九步合成方法。以d -核糖为原料，经过9个步骤合成，总产率为9.5%。设计的路线提供了数毫克级的材料。
A practical nine-step synthesis of an alpha-/beta-anomeric mixture of glycinamide ribonucleotide (GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 9.5% overall yield. The route as devised provided material on the multi-milligram scale.