HIV-inducing factor in cervicovaginal secretions is associated with bacterial vaginosis in HIV-1-infected women
HIV-inducing factor in cervicovaginal secretions is associated with bacterial vaginosis in HIV-1-infected women
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DOI：
10.1097/01.qai.0000146599.47925.e0
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发表时间：
2005-07-01
影响因子：
3.6
通讯作者：
Spear, GT
中科院分区：
文献类型：
--
作者：
Cohn, JA;Hashemi, FB;Spear, GT
目的：从 HIV-1 感染和未感染女性中获取的某些宫颈阴道灌洗 (CVL) 液体样本可刺激 HIV-1 体外复制。这种活性，即 HIV 诱导因子 (HIF)，会在以下情况下发生变化： CVL 液体被加热。我们试图证实之前的观察结果，即 HIF 与细菌性阴道病 (BV) 相关。方法：在从 HIV-1 感染女性获得的未加热和加热的 CVL 液体中测量 HIF，并通过 Nugent 评分、其他生殖道状况和宫颈阴道 HIV-1 脱落情况与 BV 的存在情况进行比较。结果：在研究的 295 名女性中。 54% 的 CVL 样品具有 HIF 活性，21% 具有热稳定性 HIF 活性。在调整后的逻辑回归中，热稳定 HIF 与 BV（比值比 [OR] = 51.7，95% 置信区间 [CI]：5.0 530.7）和中间菌群相关（OR = 43.3，95% CI：3.6，521.1）；热不稳定的 HIF 与 BV 无关 热稳定和热不稳定的 HIF 均与其他宫颈阴道疾病无关，在控制血浆病毒载量后，也与生殖道 HIV-1 脱落无关。结论：我们证实了 HIF 与 BV 的关联，并将其归因于热稳定成分。热稳定活性也与阴道中间菌群相关，尽管不太强烈。我们认为热稳定性 HIF 是 BV 相关细菌产物的结果。
Objective: Certain cervicovaginal lavage (CVL) fluid samples obtained from HIV-1-infected and uninfected women stimulate in vitro HIV-1 replication. This activity, HIV-inducing factor (HIF), changes when: CVL fluid is heated. We sought to confirm a previous observation that HIF was associated with bacterial vaginosis (BV).Methods: HIF was measured in unheated and heated CVL fluid obtained from HIV-1-infected women and compared with the presence of BV by Nugent scores, other genital tract conditions, and cervicovaginal HIV-1 shedding.Results: Among the 295 women studied. 54% of CVL samples had HIF activity and 21% showed heat-stable HIF activity. In adjusted logistic regression, heat-stable HIF was associated with BV (odds ratio [OR] = 51.7, 95% confidence interval [CI]: 5.0 530.7) and with intermediate flora (OR = 43.3, 95% CI: 3.6, 521.1); heat-labile HIF was not associated with BV Neither heat-stable nor heat-labile HIF was associated with other cervicovaginal conditions nor, after controlling for plasma viral load, with genital tract HIV-1 shedding.Conclusion: We confirmed the association of HIF with BV and attribute it to the heat-stable component. Heat-stable activity is also associated, although less strongly, with intermediate vaginal flora. We propose that heat-stable HIF is a result of products of BV-associated bacteria.