Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices
Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices
复制标题
DOI：
10.1126/scirobotics.aah6451
复制
发表时间：
2017-01-18
期刊：
影响因子：
25
通讯作者：
Sia, Samuel K.
中科院分区：
文献类型：
--
作者：
Chin, Sau Yin;Poh, Yukkee Cheung;Sia, Samuel K.
可植入微型装置通常具有静态组件而不是移动部件，并且表现出有限的生物相容性。本文展示了一种快速制造方法，可以在生物相容性材料中产生数十微米的尺寸，每层都有复杂的复合图案。通过利用水凝胶的独特机械性能，我们开发了一种“锁定机制”，用于精确驱动和移动自由移动的部件，可提供阀门、歧管、转子、泵和有效载荷输送等功能。水凝胶组分可以在宽范围的机械和扩散性质内调节，并且可以在植入后在没有持续电源的情况下进行控制。在骨肉瘤的小鼠模型中，在标准全身化疗剂量的（1）/10时，在10天内触发多柔比星从装置中释放显示出高治疗功效和低毒性。总的来说，这个被称为可植入微机电系统（iMEMS）的平台能够开发具有广泛复杂移动组件的生物相容性可植入微型设备，这些移动组件可以按需无线控制，从而解决设备供电和生物相容性问题。
Implantable microdevices often have static components rather than moving parts and exhibit limited biocompatibility. This paper demonstrates a fast manufacturing method that can produce features in biocompatible materials down to tens of micrometers in scale, with intricate and composite patterns in each layer. By exploiting the unique mechanical properties of hydrogels, we developed a "locking mechanism" for precise actuation and movement of freely moving parts, which can provide functions such as valves, manifolds, rotors, pumps, and delivery of payloads. Hydrogel components could be tuned within a wide range of mechanical and diffusive properties and can be controlled after implantation without a sustained power supply. In a mouse model of osteosarcoma, triggering of release of doxorubicin from the device over 10 days showed high treatment efficacy and low toxicity, at (1)/10 of the standard systemic chemotherapy dose. Overall, this platform, called implantable microelectromechanical systems (iMEMS), enables development of biocompatible implantable microdevices with a wide range of intricate moving components that can be wirelessly controlled on demand, in a manner that solves issues of device powering and biocompatibility.