Botox treatment in adductor spasmodic dysphonia: A meta-analysis
Botox treatment in adductor spasmodic dysphonia: A meta-analysis
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DOI：
10.1044/1092-4388(2002/037
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发表时间：
2002-06-01
影响因子：
2.6
通讯作者：
Bender, B
中科院分区：
文献类型：
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作者：
Boutsen, F;Cannito, MR;Bender, B
多年来，已经进行了许多研究，以记录A型肉毒毒素在内收肌痉挛性发声障碍中的治疗效果。这些研究的结果导致了这样的观点，即总体肉毒杆菌毒素治疗是中等有效的。本研究从定性和定量两个方面对疗效研究进行了回顾，以确定这一结论在多大程度上得到了数据的充分支持。尽管数据表明肉毒杆菌毒素治疗的结果是中度的总体改善，但它们也表明患者、测量和治疗条件之间存在显著差异。这一结果，加上BT疗效研究的方法学局限性和缺乏标准化，证明在推断BT治疗内收肌痉挛性发声障碍的益处时应谨慎。
Over the years many studies have been conducted to document the treatment effects of Botulinum toxin type A in adductor spasmodic dysphonia. The results of these studies have led to the view that overall Botulinum toxin treatment is moderately effective. This study reviews efficacy research qualitatively and quantitatively to determine the extent to which this conclusion is fully supported by the data. Although the data indicate moderate overall improvement as a result of Botulinum toxin treatment, they also suggest significant variation across patients, measurements, and treatment conditions. This result, together with methodological limitations and lack of standardization in BT efficacy research, justifies caution when making inferences regarding BT treatment benefit in adductor spasmodic dysphonia.