Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model.
Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model.
复制标题
膜性肾病与其他肾病亚型的比较分析及诊断模型的建立。
DOI：
10.1007/s11684-018-0620-5
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang Dong
中科院分区：
文献类型：
--
作者：
Zhu Hanyu;Fu Bo;Wang Yong;Gao Jing;Han Qiuxia;Geng Wenjia;Yang Xiaoli;Cai Guangyan;Chen Xiangmei;Zhang Dong
本研究旨在比较膜性肾病（MN）与非膜性肾病（non-MN）的临床特点，探讨其临床鉴别诊断，并建立MN的诊断模型。获得肾活检后，798例患者根据检查结果分为两组：原发性MN组（n= 248）和非MN组（n= 550）。对所得数据进行统计学分析。Logistic回归分析显示抗PLA 2 R抗体、IgG和Cr与MN独立相关，并以此3个参数建立MN诊断模型。受试者工作特征（ROC）曲线证实，我们的诊断模型可以区分患者与非MN，其相应的敏感性，特异性和AUC分别为79.9%，89.4%和0.917。该组合在MN诊断中的截止值为0.34。所建立的多因素联合诊断模型在鉴别原发性MN与其他肾脏疾病方面具有广泛的临床应用前景，为肾脏疾病的无创诊断提供了可靠依据。
This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n= 248) and non-MN group (n= 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.