Imbalance of angiogenesis in diabetic complications: the mechanisms.
Imbalance of angiogenesis in diabetic complications: the mechanisms.
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DOI：
10.4103/2008-7802.104853
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发表时间：
2012-12
影响因子：
2.1
通讯作者：
Khazaei M
中科院分区：
文献类型：
--
作者：
Tahergorabi Z;Khazaei M
2型糖尿病是一种复杂的疾病，也是一个慢性卫生保健问题。目前，由于生活方式的改变，如缺乏运动、摄入高脂饮食、肥胖和人口老龄化，糖尿病在世界范围内的患病率正在迅速上升。国际糖尿病联合会在2008年估计，全球有2.46亿成年人患有糖尿病，预计到2025年，糖尿病的患病率将达到3.8亿。尽管目前糖尿病的治疗主要集中在高血糖上，但已有文献证明血管生成异常可能在糖尿病并发症的发病机制中起作用。血管生成是指在原有血管的基础上生成新的血管。正常的血管生成依赖于血管生成因子(如血管内皮生长因子、成纤维细胞生长因子2、转化生长因子-β、血管生成素)和血管抑制因子(血管抑素、内皮抑素、血小板反应素)之间的复杂平衡。包括视网膜和肾脏在内的不同组织中的血管异常可在糖尿病微血管并发症的发病机制中发挥作用，血管损伤也可导致大血管并发症，如糖尿病神经病变和冠脉侧支形成障碍。因此，识别糖尿病并发症的不同机制可以为我们预防和/或治疗以下并发症提供机会，并提高患者和社会的生活质量。本文就糖尿病微血管和大血管并发症的血管生成机制作一综述。
Type 2 diabetes mellitus is a complex disease and a chronic health-care problem. Nowadays, because of alteration of lifestyle such as lack of exercise, intake of high fat diet subsequently obesity and aging population, the prevalence of diabetes mellitus is increasing quickly in around the world. The international diabetes federation estimated in 2008, that 246 million adults in worldwide suffered from diabetes mellitus and the prevalence of disease is expected to reach to 380 million by 2025. Although, mainly in management of diabetes focused on hyperglycemia, however, it is documented that abnormalities of angiogenesis may contribute in the pathogenesis of diabetes complications. Angiogenesis is the generation of new blood vessels from pre-existing ones. Normal angiogenesis depends on the intricate balance between angiogenic factors (such as VEGF, FGF2, TGF-β, angiopoietins) and angiostatic factors (angiostatin, endostatin, thrombospondins). Vascular abnormalities in different tissues including retina and kidney can play a role in pathogenesis of micro-vascular complications of diabetes; also vascular impairment contributes in macrovascular complications e.g., diabetic neuropathy and impaired formation of coronary collaterals. Therefore, identifying of different mechanisms of the diabetic complications can give us an opportunity to prevent and/or treat the following complications and improves quality of life for patients and society. In this review, we studied the mechanisms of angiogenesis in micro-vascular and macro-vascular complications of diabetes mellitus.