The interactions and dissociations of the dorsal hippocampus subregions: How the dentate gyrus, CA3, and CA1 process spatial information
The interactions and dissociations of the dorsal hippocampus subregions: How the dentate gyrus, CA3, and CA1 process spatial information
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DOI：
10.1037/0735-7044.122.1.16
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发表时间：
2008-02-01
影响因子：
1.9
通讯作者：
Kesner, Raymond P.
中科院分区：
文献类型：
--
作者：
Goodrich-Hunsaker, Naomi J.;Hunsaker, Michael R.;Kesner, Raymond P.
一些研究已经证明了空间认知地图的重要性及其在环境中引导和精确导航的作用。空间知识的学习和记忆依赖于正确的拓扑和度量空间信息处理。目前的目标是更好地表征海马体在处理拓扑和度量空间信息方面的作用。海马背侧分区域病变（dDG, dCA3, dCA1）的大鼠在先前建立的度量任务和拓扑任务中进行测试。本研究结果表明，dCA1介导拓扑记忆，而不是dDG或dCA3。此外，dDG、dCA3和dCA1调解度量内存。通过模式分离或感觉输入的正交化来生成度量表示，需要背侧DG进行空间信息处理。然后，背侧CA3和dCA1沿着三突触环路接收来自dDG的这些度量表征。目前的数据增加了越来越多的文献表明海马亚区之间的功能多样性。
Several studies have demonstrated the significance of a spatial cognitive map and its role for guided and accurate navigation through the environment. Learning and recalling spatial knowledge depends upon proper topological and metric spatial information processing. The present objectives are to better characterize the role of the hippocampus for processing topological and metric spatial information. Rats with dorsal hippocampal subregional lesions (dDG, dCA3, dCA1) were tested on a previously established metric task and topological task. The results of the present study suggest that dCA1, but not dDG or dCA3, mediates topological memory. Furthermore, dDG, dCA3, and dCA1 mediate metric memory. Dorsal DG is required for spatial information processing via pattern separation or orthogonalization of sensory inputs to generate metric representations. Dorsal CA3 and dCA1 then receive these metric representations transmitted from dDG along the trisynaptic loop. The present data add to a growing body of literature suggesting a diversity of function among the hippocampal subregions.