Response of SI cortex to ipsilateral, contralateral and bilateral flutter stimulation in the cat.
Response of SI cortex to ipsilateral, contralateral and bilateral flutter stimulation in the cat.
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DOI：
10.1186/1471-2202-6-29
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发表时间：
2005-04-22
期刊：
影响因子：
2.4
通讯作者：
Whitsel B
中科院分区：
文献类型：
--
作者：
Tommerdahl M;Simons SB;Chiu JS;Favorov O;Whitsel B
虽然SII皮质被认为是整合来自身体两侧的触觉信息的通路的第一个皮质阶段，但SI皮质通常不被认为是通过同时刺激双侧(和镜像)皮肤部位来调节神经元反应的区域。用光学内源信号成像技术评价同侧大脑半球SI和SII对25 Hz正弦垂直皮肤位移刺激(“皮肤扑动”)对对侧、同侧和双侧(同时)前爪中央垫的反应。对侧和双侧扑动刺激后，SI和SII的吸光度均有局部增加。同侧扑动刺激可引起SII吸光度局部增加，但SI吸光度变化很小或无变化。然而，在SI的前爪代表区，双侧中央垫的刺激引起的反应比对侧中央垫的扑动刺激引起的反应小得多(大约30-35%)。双侧大脑皮质对扑动刺激的反应明显小于对侧扑动刺激的反应，再加上最近发表的一项观察，即位于SII后方的区域对双侧扑动刺激的反应比对侧中央垫的反应大得多，这导致我们提出，对侧皮肤刺激引起的SI活动受到抑制/抑制(通过同一半球SII和SI之间的皮质联系)，这是由于同时同侧皮肤刺激在SII后部引起的活动。
While SII cortex is considered to be the first cortical stage of the pathway that integrates tactile information arising from both sides of the body, SI cortex is generally not considered as a region in which neuronal response is modulated by simultaneous stimulation of bilateral (and mirror-image) skin sites. Optical intrinsic signal imaging was used to evaluate the response of SI and SII in the same hemisphere to 25 Hz sinusoidal vertical skin displacement stimulation ("skin flutter") applied contralaterally, ipsilaterally, and bilaterally (simultaneously) to the central pads of the forepaws. A localized increase in absorbance in both SI and SII occurred in response to both contralateral and bilateral flutter stimulation. Ipsilateral flutter stimulation evoked a localized increase in absorbance in SII, but little or no change in SI absorbance. In the forepaw representational region of SI, however, bilateral stimulation of the central pads evoked a response substantially smaller (approximately 30–35% smaller) than the response to flutter stimulation of the contralateral central pad. The finding that the response of SI cortex to bilateral central pad flutter stimulation is substantially smaller than the response evoked by a contralateral flutter stimulus, together with the recently published observation that a region located posteriorly in SII responds with a substantially larger response to a bilateral flutter stimulus than the response evoked from the contralateral central pad, lead us to propose that the SI activity evoked by contralateral skin stimulation is suppressed/inhibited (via corticocortical connections between SII and SI in the same hemisphere) by the activity a simultaneous ipsilateral skin stimulus evokes in posterior SII.
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