Levels of fatigue compared to levels of cytokines and hemoglobin during pelvic radiotherapy: a pilot study.
Levels of fatigue compared to levels of cytokines and hemoglobin during pelvic radiotherapy: a pilot study.
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DOI：
10.1177/1099800403259500
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发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Gaston-Johansson, Fannie
中科院分区：
文献类型：
--
作者：
Ahlberg, Karin;Ekman, Tor;Gaston-Johansson, Fannie
癌症相关性疲劳（CRF）是癌症治疗期间患者经历的普遍且令人痛苦的症状。一种提出的疲劳发展的机制是促炎细胞因子的分泌增加和/或贫血的发展。这项初步研究的主要目的是调查放射治疗期间的疲劳和细胞因子水平，并确定两者之间是否存在相关性。第二个目的是探讨血红蛋白值，细胞因子和疲劳之间的关系。参与者包括15名被诊断患有子宫癌的妇女，她们接受了治疗性外部放射治疗。通过自我报告工具（多维疲劳量表[MFI-20]）评估疲劳，并在放疗前、放疗期间和放疗后测量血红蛋白和细胞因子（IL-1、IL-6和TNF-α）。放疗期间疲劳程度增加，而IL-1、IL-6或TNF-α水平无显著变化。全身疲劳的变化与IL-1和TNF-α的变化之间无显著相关性。IL-6的变化与全身疲劳呈显著负相关。放疗期间血红蛋白水平确实显著降低，但在治疗3周后或治疗完成后，全身疲劳与血红蛋白之间无显著相关性。总之，子宫癌患者的盆腔放疗与疲劳增加有关。贫血或细胞因子水平与疲劳之间没有显著关系。放射治疗期间疲劳的发病机制仍有待阐明。
Cancer-related fatigue (CRF) is a prevalent and distressing symptom experienced by patients during cancer therapy. One proposed mechanism for the development of fatigue is the increased secretion of proinflammatory cytokines and/or the development of anemia. The major purpose of this pilot study was to investigate the levels of fatigue and cytokines during radiation therapy and determine whether there was a correlation between the two. A secondary purpose was to explore the relationships among hemoglobin values, cytokines, and fatigue. Participants included 15 women diagnosed with uterine cancer, who received curative external radiation therapy. Fatigue was assessed by a self-report instrument (Multidimensional Fatigue Inventory [MFI-20]) and hemoglobin and cytokines (Il-1, Il-6, and TNF-alpha) were measured before, during, and after radiotherapy. The degree of fatigue increased during radiotherapy without a significant change in IL-1, IL-6, or TNF-alpha levels. There was no significant correlation between changes in general fatigue and the changes in IL-1 and TNF-alpha. There was a significant negative correlation between the change in IL-6 and general fatigue. The hemoglobin levels did decrease significantly during radiotherapy, but there was no significant correlation between general fatigue and hemoglobin after 3 weeks of therapy or after the completion of therapy. In conclusion, pelvic radiotherapy in women with uterine cancer is associated with increased fatigue. There were no significant relationships between anemia or cytokine levels and fatigue. The pathogenesis of fatigue during radiation therapy remains to be elucidated.