Osteosarcoma, chondrosarcoma, and Ewing's sarcoma
Osteosarcoma, chondrosarcoma, and Ewing's sarcoma
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DOI：
10.1097/blo.0b013e318059b8c9
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发表时间：
2007-06-01
影响因子：
4.2
通讯作者：
Stewart, Andrew
中科院分区：
文献类型：
--
作者：
Damron, Timothy A.;Ward, William G.;Stewart, Andrew
我们总结了1985年至2003年美国外科医师学会国家癌症数据库中26,437例骨肉瘤(n=11,961)、软骨肉瘤(n=9606)和尤文氏肉瘤(n=4870)的描述性流行病学和生存数据。报告的生存数据是从1985年到1998年至少随访5年的病例(骨肉瘤8,104例，软骨肉瘤6,476例，尤文氏肉瘤3,225例)。骨肉瘤、软骨肉瘤和尤文肉瘤的5年相对生存率分别为53.9%、75.2%和50.6%。在收集期间，存活率没有明显变化。在骨肉瘤中，高级别、骨旁和Paget亚型的5年相对生存率分别为52.6%、85.9%和17.8%。对于骨肉瘤患者，30岁以下的患者相对5年生存率为60%，30-49岁的患者为50%，50岁或以上的患者为30%。在软骨肉瘤中，传统组的5年相对生存率为76%，粘液组为71%，皮质旁组为87%，间叶组为52%。虽然国家癌症数据库有局限性，但骨肉瘤的生存数据和人口学数据在数量和持续时间上都是前所未有的。我们的报告支持继续努力完善数据收集和促进进一步的数据分析。
We summarize descriptive epidemiologic and survival data from the National Cancer Data Base of the American College of Surgeons for 26,437 cases of osteosarcoma (n = 11,961), chondrosarcoma (n = 9606), and Ewing's sarcoma (n = 4870) from 1985 to 2003. Survival data are reported on cases with a minimum 5-year followup from 1985 to 1998 (8,104 osteosarcomas, 6,476 chondrosarcomas, and 3,225 Ewing's sarcomas). The relative 5-year survival rate was 53.9% for osteosarcoma, 75.2% for chondrosarcoma, and 50.6% for Ewing's sarcoma. Survival rates did not change notably over the collection period. Within osteosarcomas, the relative 5-year survival rates were 52.6% for high grade, 85.9% for parosteal, and 17.8% for Paget's subtypes. For osteosarcoma patients, the relative 5-year survival rate was 60% for those younger than 30 years, 50% for those aged 30 to 49 years, and 30% for those aged 50 years or older. Within chondrosarcomas, the relative 5-year survival rate was 76% for conventional, 71 % for myxoid, 87 % for juxtacortical, and 52 % for mesenchymal. While the National Cancer Data Base has limitations, the survival data and demographics for bone sarcomas are unprecedented in numbers and duration. Our report supports continued efforts to refine data collection and stimulate further data analysis.