GONADAL-STEROIDS - EFFECTS ON EXCITABILITY OF HIPPOCAMPAL PYRAMIDAL CELLS
GONADAL-STEROIDS - EFFECTS ON EXCITABILITY OF HIPPOCAMPAL PYRAMIDAL CELLS
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DOI：
10.1126/science.7190730
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
RAWITCH, AB
中科院分区：
文献类型：
--
作者：
TEYLER, TJ;VARDARIS, RM;RAWITCH, AB
在培养液中加入1 × 10 ~（-10）M的雌二醇和睾酮，引起大鼠海马脑片的电生理场电位随性别的不同而不同。雄性大鼠的切片显示对雌二醇的兴奋性增加，而对睾酮的兴奋性没有增加。雌鼠切片不受雌二醇影响，但动情间期雌鼠切片对睾酮的兴奋性增加，而动情前期雌鼠切片的兴奋性降低。
Electrophysiological field potentials from hippocampal slices of rat brain show sex-linked differences in response to 1 × 10-10Mconcentrations of estradiol and testosterone added to the incubation medium. Slices from male rats show increased excitability to estradiol and not to testosterone. Slices from female rats are not affected by estradiol, but slices from female rats in diestrus show increased excitability in response to testosterone whereas slices from females in proestrus show decreased excitability.