Zero in the brain: A voxel-based lesion-symptom mapping study in right hemisphere damaged patients
Zero in the brain: A voxel-based lesion-symptom mapping study in right hemisphere damaged patients
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DOI：
10.1016/j.cortex.2016.01.011
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发表时间：
2016-04-01
期刊：
影响因子：
3.6
通讯作者：
Semenza, Carlo
中科院分区：
文献类型：
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作者：
Benavides-Varela, Silvia;Passarini, Laura;Semenza, Carlo
转码包含零的数字比转码由非零数字形成的数字更有问题。然而，目前尚不清楚这是否是由于零需要大脑区域而不是传统上与数字表示相关的区域。在这里，我们假设，转码零需要视觉空间和整合的过程通常与右半球。这项研究涉及22名右脑受损的患者和20名健康对照者，他们完成了阅读和书写阿拉伯数字的测试。正如预期的那样，患者中最严重的缺陷涉及无法科普零。此外，基于体素的病变症状映射（VLSM）分析表明，最常见的零错误最大程度地与右前额叶相关，这是以前与感觉运动整合，注意力和反应选择，但第一次与转码过程。涉及其他数字的错误类别对应于所谓的Needle错误，然而，仅占患者总阅读错误的10%和书写错误的3%。我们认为，对右半球的损害损害的机制，解析，并建立空槽结构所需的处理零的复数的能力，此外，我们认为，位于靠近右半球的大脑区域发挥的作用，在整合的信息所产生的临时应用程序的代码转换程序。(C)2016爱思唯尔有限公司版权所有
Transcoding numerals containing zero is more problematic than transcoding numbers formed by non-zero digits. However, it is currently unknown whether this is due to zeros requiring brain areas other than those traditionally associated with number representation. Here we hypothesize that transcoding zeros entails visuo-spatial and integrative processes typically associated with the right hemisphere. The investigation involved 22 right-brain damaged patients and 20 healthy controls who completed tests of reading and writing Arabic numbers. As expected, the most significant deficit among patients involved a failure to cope with zeros. Moreover, a voxel-based lesion symptom mapping (VLSM) analysis showed that the most common zero-errors were maximally associated to the right insula which was previously related to sensorimotor integration, attention, and response selection, yet for the first time linked to transcoding processes. Error categories involving other digits corresponded to the so-called Neglect errors, which however, constituted only about 10% of the total reading and 3% of the writing mistakes made by the patients. We argue that damage to the right hemisphere impairs the mechanism of parsing, and the ability to set-up empty-slot structures required for processing zeros in complex numbers; moreover, we suggest that the brain areas located in proximity to the right insula play a role in the integration of the information resulting from the temporary application of transcoding procedures. (C) 2016 Elsevier Ltd. All rights reserved.