Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study
Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study
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DOI：
10.1038/sj.ejcn.1601830
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发表时间：
2004-03-01
影响因子：
4.7
通讯作者：
Terasawa, K
中科院分区：
文献类型：
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作者：
Hirayama, S;Hamazaki, T;Terasawa, K
目的：为探讨补充二十二碳六烯酸（DHA）是否能改善注意力缺陷/多动障碍（AD/HD）儿童的症状，设计和研究对象：40名6-12岁的AD/HD（包括8名AD/HD疑似）儿童进行安慰剂对照的双盲研究。DHA组（n = 20）的受试者服用含有鱼油的活性食物（发酵豆浆、面包卷和馒头;每周从这些食物中摄取3.6 g DHA）2个月，而对照组（n = 20）的受试者服用不含鱼油的无区别对照食物。在研究开始和结束时测量以下项目：（1）注意缺陷、多动和冲动（根据DSM-IV标准的AD/HD相关症状）;（2）父母和教师评估的攻击性;（3）视觉感知（4）视觉和听觉短时记忆;（5）视觉-运动整合的发展;（6）连续性表现;（7）不耐烦。结果：实验1、2、3、5和7随时间的变化在两组之间没有显著差异。然而，与DHA组随时间的变化相比，对照组的视觉短期记忆和任务错误（连续性能）显著改善（分别为P = 0.02和0.001）。重新计算没有AD/HD怀疑受试者（n = 4每组）表现出类似的P值方面的两个measurement.Conclusion：DHA补充剂没有改善AD/HD相关症状。用脂肪酸治疗ADHD值得进一步研究，但应仔细注意使用哪种脂肪酸。
Objectives: To investigate whether docosahexaenoic acid (DHA) supplementation was able to ameliorate attention-deficit/hyperactivity disorder(AD/HD) symptoms in AD/HD children.Design and subjects: A placebo-controlled double-blind study with 40 AD/HD (including eight AD/HD-suspected) children of 6-12 y of age who were mostly without medication. Subjects of a DHA group (n = 20) took active foods containing fish oil (fermented soybean milk, bread rolls and steamed bread; 3.6 g DHA/week from these foods) for 2 months, whereas those of a control group (n = 20) took indistinguishable control foods without fish oil. The following items were measured at the start and end of the study: (1) attention deficit, hyperactivity and impulsivity (AD/HD-related symptoms according to DSM-IV criteria); (2) aggression assessed by both parents and teachers; (3) visual perception ( finding symbols out of a table); (4) visual and auditory short-term memory; (5) development of visual-motor integration; (6) continuous performance; (7) impatience.Results: Changes in tests 1, 2, 3, 5 and 7 over time did not significantly differ between the two groups. However, visual short-term memory and errors of commission (continuous performance) significantly improved in the control group compared with the changes over time in the DHA group (P = 0.02 and 0.001, respectively). Recalculation without AD/HD-suspected subjects (n = 4 each group) showed similar P-values with regard to both measures.Conclusion: DHA supplementation did not improve AD/HD-related symptoms. Treatment of ADHD with fatty acids deserves further investigation, but careful attention should be paid as to which fatty acid(s) is used.