Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination
Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination
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DOI：
10.1016/j.vaccine.2009.03.085
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发表时间：
2009-06-08
期刊：
影响因子：
5.5
通讯作者：
Clemens, John
中科院分区：
文献类型：
--
作者：
Ali, Mohammad;Emch, Michael;Clemens, John
我们重新分析了灭活口服霍乱疫苗 III 期试验的数据，以检验两个假设：疫苗在感染力较低的地区会产生更大的影响，大规模疫苗接种活动后疾病传播的空间格局将发生变化。使用空间回归来检验这些假设，说明疾病和疫苗覆盖率的空间异质性。分析结果证实了这两个假设。该论文还展示了当疾病分布存在空间异质性时，如何使用空间分析来了解疫苗接种的影响。 (C) 2009 Elsevier Ltd. 保留所有权利。
We reanalyzed data from a phase III trial for the killed oral cholera vaccine to test two hypotheses: there will be a greater impact of the vaccine in areas where there is a low force of infection, and the spatial pattern of disease transmission will change after a mass vaccination campaign. Spatial regression was used to test these hypotheses accounting for spatial heterogeneity in disease and vaccine coverage. The results of the analyses confirm both hypotheses. The paper also shows how spatial analysis can be used to understand the impact of vaccination when there are spatially heterogeneous disease distributions. (C) 2009 Elsevier Ltd. All rights reserved.