EFFECTS OF AGING ON FOOD-ENTRAINED CIRCADIAN-RHYTHMS IN THE RAT
EFFECTS OF AGING ON FOOD-ENTRAINED CIRCADIAN-RHYTHMS IN THE RAT
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DOI：
10.1016/0197-4580(90)90027-w
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发表时间：
1990-11-01
影响因子：
4.2
通讯作者：
MOOREEDE, MC
中科院分区：
文献类型：
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作者：
MISTLBERGER, RE;HOUPT, TA;MOOREEDE, MC
24小时的受限食物供应时间表通过食物携带的起搏器与光携带的起搏器分开，在大鼠的昼夜活动节律中包含了一个组成部分。在6只3-21个月龄和24-25个月龄大鼠上，观察了衰老对摄食昼夜节律的影响。在20-21个月龄的轮式笼子中，老年大鼠的食物夹带是明显的，测量的是在光照期间对每天1小时进餐时间的行为预期，以及在食物剥夺期间这种预期节律的持续性。尽管白天进食受到限制的时间很长，但老年大鼠和年轻大鼠一样，在过渡到临时喂养时，很快就恢复了夜间活动。当24月龄恢复限制日喂食时，这些大鼠需要更多的时间才能形成食物预期模式，并且与一组年轻的成年大鼠相比，表现出较低的食物预期节律。这些与年龄相关的变化类似于光携带昼夜节律的特征，表明大鼠‘S’多振荡昼夜节律计时系统的两个组成部分在一生中平行恶化。
Twenty-four hour schedules of restricted food availability entrain a component of the circadian activity rhythm in rats via a food-entrainable pacemaker separate from the light-entrainable pacemaker. The effect of aging on food-entrained circadian rhythms was examined in 6 rats maintained on a restricted diurnal feeding schedule from age 3-21 months and again from 24-25 months. Food-entrainment, measured as behavioral anticipation of a 1-hr daily mealtime during the middle of the light period and persistence of this anticipation rhythm during food deprivation, was apparent in the aged rats when recorded in wheel-running cages from 20-21 months of age. Despite the long duration of restricted diurnal food access, the aged rats, like young rats, rapidly reverted to nocturnal activity when transferred to ad lib feeding. When restricted diurnal feeding was reinstated at 24 months of age, these rats, now recorded in food-bin monitoring cages, required more time for a food anticipation pattern to emerge and showed a lower amplitude food anticipation rhythm compared to a group of young adult rats. These age-related changes are similar to those that characterize photically entrained circadian rhythms and suggest that both components of the rat''s multioscillatory circadian timekeeping system deteriorate in parallel over the life span.