A HD-ZIP transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms in tomato.
A HD-ZIP transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms in tomato.
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DOI：
10.1016/j.devcel.2023.01.009
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发表时间：
2023-02
影响因子：
11.8
通讯作者：
Minliang Wu;Jiang Chang;Xiaoqian Han;JingYuan Shen;Liling Yang;Shourong Hu;Benben Huang;
中科院分区：
文献类型：
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作者：
Minliang Wu;Jiang Chang;Xiaoqian Han;JingYuan Shen;Liling Yang;Shourong Hu;Benben Huang;
毛状结构是大多数生物体所共有的。植物表面的毛，通常被称为毛状体，形成不同的类型，以感知和保护免受各种压力。然而，目前还不清楚毛状体如何分化成高度可变的形式。在这里，我们表明，同源结构域亮氨酸拉链（HD-ZIP）转录因子命名为羊毛控制不同的毛状体在番茄通过剂量依赖性机制的命运。Woolly的自催化强化被一个自动调节负反馈回路抵消，产生一个具有高或低Woolly水平的回路。这使导致不同毛状体类型的单独拮抗级联的转录激活偏置。我们的研究结果确定了毛状体形成的发育开关，并为植物中的渐进命运规范提供了机制见解，以及增强植物抗逆性和有益化学物质生产的途径。
Hair-like structures are shared by most living organisms. The hairs on plant surfaces, commonly referred to as trichomes, form diverse types to sense and protect against various stresses. However, it is unclear how trichomes differentiate into highly variable forms. Here, we show that a homeodomain leucine zipper (HD-ZIP) transcription factor named Woolly controls the fates of distinct trichomes in tomato via a dosage-dependent mechanism. The autocatalytic reinforcement of Woolly is counteracted by an autoregulatory negative feedback loop, creating a circuit with a high or low Woolly level. This biases the transcriptional activation of separate antagonistic cascades that lead to different trichome types. Our results identify the developmental switch of trichome formation and provide mechanistic insights into the progressive fate specification in plants, as well as a path to enhancing plant stress resistance and the production of beneficial chemicals.