The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat
The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat
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DOI：
10.1016/s0006-8993(99)02301-x
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发表时间：
2000-01-17
期刊：
影响因子：
2.9
通讯作者：
O'Byrne, KT
中科院分区：
文献类型：
--
作者：
Cates, PS;O'Byrne, KT
尾侧脑干参与了葡萄糖拮抗对生殖神经内分泌轴的抑制作用，特别是抑制了大鼠促性腺激素释放激素(GnRH)/黄体生成素(LH)的释放。在本研究中，去掉最后区域完全阻止了胰岛素诱导的低血糖应激对脉动性黄体生成素释放的深刻抑制作用。这些结果表明，这种脑干结构在调节低血糖应激对下丘脑GnRH脉冲发生器的抑制中起着关键作用。(C)2000 Elsevier Science B.V.保留所有权利。
The caudal brainstem has been implicated in mediating the suppressive effect of glucoprivation on the reproductive neuroendocrine axis, specifically inhibition of pulsatile gonadotrophin-releasing hormone (GnRH)/luteinising hormone (LH) release in the rat. In the present study, removal of the area postrema completely prevented the profound inhibitory effect of insulin-induced hypoglycaemic stress on pulsatile LH release. These results suggest a pivotal role for this brainstem structure in mediating hypoglycaemic stress-induced suppression of the hypothalamic GnRH pulse generator. (C) 2000 Elsevier Science B.V. All rights reserved.