Cognitive functioning and health related quality of life after rupture of an aneurysm on the anterior communicating artery versus middle cerebral artery
Cognitive functioning and health related quality of life after rupture of an aneurysm on the anterior communicating artery versus middle cerebral artery
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DOI：
10.1080/02688690902785701
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发表时间：
2009-01-01
影响因子：
1.1
通讯作者：
Finset, Arnstein
中科院分区：
文献类型：
--
作者：
Haug, Tonje;Sorteberg, Angelika;Finset, Arnstein
SAH后的神经心理结果和健康相关生活质量（HRQOL）被认为与破裂动脉瘤的位置无关。这一观点需要验证，因为当代有更灵敏的神经心理学测试和最近对SAH后异常行为的临床观察。为此，我们分别比较了前交通动脉（ACoA） （n=24）和大脑中动脉（MCA） （n=22）动脉瘤破裂的患者。所有患者在SAH后12个月接受了广泛的神经心理学检查、临床访谈和问卷调查。我们发现两组患者在认知功能的许多领域的测试分数与人群标准有轻度到中度的差异，尽管MCA动脉瘤破裂患者最初的临床状况较差，并且更常发生颅内血肿，但MCA患者的功能改善趋势一致，但在统计学上不显著。我们观察到，在Delis-Kaplan执行功能系统（D-KEFS）测试的第一条件下，ACoA患者的执行功能略有下降，以及一些记忆功能的测量。ACoA患者似乎在开始解决问题的行为方面存在问题。没有任何一组患者在冷漠和抑郁方面得分。两组患者HRQOL的一些指标与人群正常值相比均有相同的降低。与MCA患者相比，ACoA患者的病假时间更长。
The neuropsychological outcome and Health Related Quality of Life (HRQOL) after SAH have been largely believed to be unrelated to the location of the ruptured aneurysm. This notion needs verification due to the contemporary availability of more sensitive neuropsychological test batteries and more recent clinical observations of deviant behaviour after SAH. To this end, we compared patients with ruptured aneurysms on respectively the anterior communicating artery (ACoA) (n=24) or middle cerebral artery (MCA) (n=22). All patients underwent an extensive neuropsychological examination, clinical interview and answered questionnaires 12 months after SAH. We found mild to moderate discrepancies from population norm in test scores on a number of areas of cognitive functioning in both patient groups, with a consistent, but statistically non-significant trend towards better functioning in MCA patients despite of the fact that patients with ruptured MCA aneurysms were initially in a poorer clinical condition and more often had intracranial haematomas. We observed slight reductions in executive functions, on the first conditions on the Delis-Kaplan Executive Functioning System (D-KEFS) tests, and some measures of memory functions in the ACoA patients. ACoA patients seemed to have problems with initiation of problem solving behaviour. None of the patient groups scored for apathy and depression. Some measures of HRQOL were equally reduced as compared to the population norm in both groups. ACoA patients remained longer on sick-leave compared to MCA patients.