Palladium-Catalyzed Regioselective C4-H Acyloxylation of Indoles with Carboxylic Acids via a Transient Directing Groups Strategy.
Palladium-Catalyzed Regioselective C4-H Acyloxylation of Indoles with Carboxylic Acids via a Transient Directing Groups Strategy.
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DOI：
10.1021/acs.orglett.3c03568
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发表时间：
2023-12
期刊：
影响因子：
5.2
通讯作者：
Xing-Long Zhang;Meng-Yue Wang;Hui-Jin Liu;Yong-Qiang Wang
中科院分区：
文献类型：
--
作者：
Xing-Long Zhang;Meng-Yue Wang;Hui-Jin Liu;Yong-Qiang Wang
开发一种高效的合成C4氧基取代吲哚的方法是一项具有挑战性的任务。在这里，我们报告了一个通用的钯催化的TDG方法用于吲哚的直接C4-H酰氧基化反应。该方案具有原子经济、步骤经济、区域选择性好、官能团耐受性好等特点。此外，该反应可以容纳包括苯甲酸、苯乙酸和脂肪酸在内的一系列羧酸。
The development of an efficient method for the synthesis of C4 oxy-substituted indoles is an appealing yet challenging task. Herein, we report a general palladium-catalyzed TDG approach for the direct C4-H acyloxylation of indoles. The protocol features atom and step economy, excellent regioselectivity, and good tolerance of functional groups. Moreover, the reaction can accommodate a range of carboxylic acids including benzoic acids, phenylacetic acids, and aliphatic acids.