Rhodium-HMPT-catalyzed direct ortho arylation of phenols with aryl bromides
Rhodium-HMPT-catalyzed direct ortho arylation of phenols with aryl bromides
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DOI：
10.1016/j.tetlet.2003.09.151
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发表时间：
2003-11-24
影响因子：
1.8
通讯作者：
Inoue, Y
中科院分区：
文献类型：
--
作者：
Oi, S;Watanabe, S;Inoue, Y
研究了六甲基磷酰三胺(HMPT)催化苯酚与芳基溴化物的直接邻位芳基化反应。一个合理的反应机理，包括由苯酚和HMPT原位生成芳基亚磷酸。提出了以磷为导向的芳基亚磷酸酯与底物苯酚的邻位金属化和酯交换反应。(C)2003爱思唯尔有限公司。保留所有权利。
Direct ortho arylation of phenols with aryl bromides catalyzed by a rhodium complex and hexamethylphosphorous triamide (HMPT) have been developed. A plausible reaction mechanism involving in situ generation of arylphosphites from phenols and HMPT. phosphorus-directed ortho metalation, and transesterification of the arylated arylphosphites with the substrate phenols is proposed. (C) 2003 Elsevier Ltd. All rights reserved.