Prof. Dr. Jan Klein (1936-2023).
Prof. Dr. Jan Klein (1936-2023).
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Jan Klein 教授、博士（1936-2023）。
DOI：
10.1007/s00251-023-01317-5
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发表时间：
2023
期刊：
影响因子：
3.2
通讯作者：
Kasahara,Masanori
中科院分区：
文献类型：
--
作者：
Bontrop,Ronald;Flajnik,Martin;O'Huigin,ColmS;Kasahara,Masanori
Jan Klein于1936年出生于捷克共和国的一个小镇Stemplovec。这一年，彼得·甘斯勒发现了主要组织相容性复合体（MHC）。1955年毕业于布拉格的查尔斯大学，获得博士学位。1965年在捷克斯洛伐克科学院。1968年，他移居美国，先后在斯坦福大学、密歇根大学、得克萨斯州和迈阿密（佛罗里达州）担任博士后和独立职位。1977年至2004年，他担任德国图宾根马克斯-普朗克生物研究所所长。退休后，他回到美国，成为弗朗西斯·R。海伦S。宾夕法尼亚州立大学科学客座教授和生物学兼职教授。最初，Jan是一名植物学家，但他最着名的是他在免疫遗传学领域的工作。他的科学遗产是巨大的。他对免疫遗传学的兴趣，特别是小鼠MHC（H2复合体），是在捷克斯洛伐克科学院培养的，在那里他开始了他的博士学位。在米兰·哈谢克的实验室工作，他独立发现了鸟类的免疫耐受现象。在那里，Jan获得了两个I类区域可通过H2复合物中的重组分离的证据。1972年，Jan和他的博士后导师Donald C.史瑞夫勒该模型阐明了困扰免疫学家的H2血清学的复杂性可以通过假设仅两个I类基因座H2-K和H2-D来解释，从而消除了对I类遗传学的相当大的混淆。简还作出了重要贡献，我们的理解II类基因座。首先，由他和其他人产生的H2重组小鼠在绘制H2复合物内的免疫反应（Ir-1）位点中发挥了重要作用。与Hugh O的合作。McDevitt发现了Ir-1基因座及其在体液适应性免疫中的作用，极大地增加了免疫学界对H2复合物的兴趣。简支持免费提供小鼠品系，这是H2先驱工作的特点。第二，Jan的小组是第一个血清学鉴定I区相关（Ia）抗原，现在称为II类分子。从这些开创性的成就中，Jan被公认为创新者
Jan Klein was born in 1936 in Stemplovec, a small town in the Czech Republic. Quite fittingly, it was also the year that Peter Gorer discovered the Major Histocompatibility Complex (MHC). Jan graduated from the Charles University in Prague in 1955 and earned his Ph. D. in 1965 at the Czechoslovak Academy of Sciences. In 1968 he moved to the USA and held postdoctoral and then independent positions at Stanford, Michigan, Texas, and Miami (FL). From 1977 to 2004 he was the director of the Max-Planck-Institut für Biologie in Tübingen, Germany. Upon his retirement he moved back to the USA as the Frances R. and Helen S. Pentz Visiting Professor of Science and adjunct professor of biology at The Pennsylvania State University. Initially Jan was trained as a botanist, but he is most famous for his work in the field of immunogenetics. His scientific legacy is enormous. His interest in immunogenetics, in particular the mouse MHC (H2 complex), was cultivated at the Czechoslovak Academy of Sciences where he started his Ph. D. work in the laboratory of Milan Hašek, who independently discovered the phenomenon of immunological tolerance in birds. There, Jan obtained evidence for two class I regions separable by recombination in the H2 complex. This work developed into the proposal of the two-locus model in 1972 by Jan and his postdoctoral mentor Donald C. Shreffler. This model formulated that the complexity of H2 serology that plagued immunologists could be accounted for by postulating only two class I loci, H2-K and H2-D, thus eliminating considerable confusion over class I genetics. Jan also made important contributions to our understanding of class II loci. First, H2 recombinant mice generated by him and by others played an essential role in mapping the immune response (Ir-1) locus within the H2 complex. This collaborative work with Hugh O. McDevitt, who discovered the Ir-1 locus and its role in humoral adaptive immunity, dramatically increased the interest of the immunological community in the H2 complex. Jan supported the free availability of mouse strains that characterized the work of the H2 pioneers. Second, Jan’s group was the first to serologically identify I-region associated (Ia) antigens, now known as class II molecules. From these seminal accomplishments, Jan was recognized as an innovator